亚急性甲状腺炎合并Graves病12例临床分析

Clinical Analysis of 12 Cases of Subacute Thyroiditis Complicated With Graves Disease

目的：探讨亚急性甲状腺炎合并 Graves 病的发病机制、临床表现、诊断、治疗及转归情况。方法回顾性分析2009年2月～2013年4月期间12例亚急性甲状腺炎合并 Graves 病患者的临床资料。结果所有患者亚急性甲状腺炎症状和体征均典型，83%患者检测结果示摄碘率和甲状腺受体抗体（TRAb）滴度均明显升高且红细胞沉降率明显增快。结论临床上对于有亚急性甲状腺炎症状伴摄碘率、TRAb 滴度显著升高及甲状腺毒性症状持续不缓解者，应考虑亚急性甲状腺炎合并 Graves 病。

Objective To discuss the pathogenesis, clinical manifestations, diagnosis, treatment of the subacute thyroiditis complicated with Graves disease. Methods Clinical data was retrospectively analyzed in 12 cases with subacute thyroiditis complicated by Graves disease from the February of 2009 to the April of 2013. Results All patients have evident signs and symptoms of subacute thyroiditis.83% of the patients showed an elevation of the uptakes of radioactive iodine and the erythrocyte sedimentation rate. The positive rate of the thyroid receptor antibody was 91%. Conclusion If patients with confirmed evidence of subacute thyroiditis were accompanied with markedly elevated titers of thyroid receptor antibody or high uptakes of radioactive iodine or persistent thyrotoxicosis, coexistence of both diseases should be suspected.