自体角膜缘干细胞移植与常规翼状胬肉切除术疗效对比

Comparison of Efficacy of Autologous Limbal Stem Cell Transplantation and Conventional Pterygium Excision

目的探讨自体角膜干细胞移植与常规翼状胬肉切除术临床疗效。方法 80例翼状胬肉患者,共96眼,按照随机数字表法分为观察组和对照组,每组40例,48眼,对照组给予单纯的翼状胬肉切除术,观察组给予翼状胬肉切除术联合自体角膜缘干细胞移植术。比较两组眼数治愈率、复发率及角膜上皮修复时间。结果观察组的治愈率95.83%,高于对照组的83.33%,复发率为4.17%,低于对照组的16.67%(P<0.05)。观察组和对照组的角膜上皮修复时间分别为(3.17±1.25)d和(5.67±1.23)d,差异具有统计学意义(P<0.05)。结论翼状胬肉切除术联合自体角膜缘干细胞移植可提高治愈率,缩短角膜上皮修复时间。

Objective To discuss the efficacy of autologous limbal stem cell transplantation and conventional pterygium excision. Methods A total of 80 patients with pterygium（96 eyes） were divided into observation group and control group by random number table, 40 cases（48 eyes） in each group. Control group accepted pterygium excision, observation group received pterygium excision combined with autologous limbal stem cell transplantation. The cure rate, recurrence rate and corneal epithelium repair time of the two groups were compared. Results The cure rate of observation group was 95.83%, higher than control group（83.33%）, the recurrence rate was 4.17%, lower than control group （16.67%） （P〈0.05）. The corneal epithelium repair time of observation group and control group were （3.17±1.25） d and （ 5.67±1.23） d, differences had statistical significance （P〈0.05）.Conclusion Pterygium excision combined with autologous limbal stem cell transplantation can significantly improve the cure rate, shorten the corneal epithelium repair time.