注射用尤瑞克林治疗分水岭脑梗死疗效观察

To Observe the Curative Effect of Urinarykallid Injection in Treatment of Cerebral Watershed Infarction

目的：观察注射用尤瑞克林治疗分水岭脑梗死疗效。方法选择2011年2月～2014年9月我院住院的66例分水岭脑梗死患者为研究对象，所有病人均不在溶栓治疗时间窗内，根据治疗方法分为对照组33例、治疗组33例，两组病人根据病情予以抗栓、补液、稳定斑块、补液、清除自由基、适当控制血压、控制血糖、预防并发症等处理，同时配合康复锻炼。治疗组同时联合注射用尤瑞克林0.15 PNA 单位加入生理盐水100 ml 静脉注射，每日1次，连用14天，治疗期间监测血压变化，治疗前后分别行 NIHSS 评分。结果治疗14天后治疗组和对照组 NIHSS 评分均明显降低，且治疗组较对照组 NIHSS 评分下降更明显（P ＜0.05），血压波动不明显（P ＞0.05）。结论注射用尤瑞克林可明显改善分水岭脑梗死能临床症状。

Objective To observe the Urinary Kallidinogenase for Injection treatment of watershed cerebral infarction. Methods From February 2011 to September 2014 in our hospital 66 cases of cerebral watershed infarction patients as the object of study, all patients were not in thrombolytic treatment time window, according to the treatment methods are divided into the control group （33 cases） and treatment group （33 cases）, two groups of patients according to the illness be antithrombotic, rehydration, stable plaque, rehydration, clear free radicals, proper control of blood pressure, glucose control, prevention of complications etc. At the same time with the rehabilitation exercise. Treatment group and combined injection of urinary kallidinogenase 0.15 PNA unit join 100 ml normal saline intravenous injection, once a day, QD for 14 days, changes of blood pressure monitoring during treatment, before and after the treatment respectively, NIHSS score. Results After 14 days of treatment, the NIHSS score of the treatment group and the control group were significantly lower than that in the control group （NIHSS）, the score decreased more significantly （P〈0.05）, the blood pressure fluctuation was not obvious （P〉0.05）. Conclusion The clinical symptoms of cerebral infarction can be improved obviously by using Urinarykallid Injection.