观察利奈唑胺治疗耐甲氧西林金黄色葡萄球菌呼吸机相关性肺炎的临床疗效

To Observe the Clinical Efficacy of Linezolid in Treatment of Ventilator-associated Pneumonia With Meticillin-resistant Staphylococcus Aureus

目的探讨利奈唑胺治疗耐甲氧西林金黄色葡萄球菌呼吸机相关性肺炎的临床疗效。方法 30例诊断为耐甲氧西林金黄色葡萄球菌所致呼吸机相关性肺炎的患者根据住院单双号顺序分为各15例的研究组和对照组,研究组接受利奈唑胺治疗,对照组接受万古霉素治疗。结果研究组和对照组治疗前血白细胞、超敏C反应蛋白、降钙素原结果比较无差异(P>0.05),治疗后有差异(P<0.05);研究组和对照组治疗的总有效率分别为73.3%和60.0%,差异具有统计学意义(P<0.05)。结论利奈唑胺治疗耐甲氧西林金黄色葡萄球菌呼吸机相关性肺炎疗效肯定。

Objective To discuss the clinical efficacy of linezolid in treatment of ventilator-associated pneumonia with meticillin-resistant staphylococcus aureus. Methods 30 patients diagnosed ventilator-associated pneumonia with meticillin-resistant staphylococcus aureus were divided into study group and control group according to hospitalization single and double, 15 cases in each group. Study group received linezolid while control group received vancomycin. Results There had no difference in the results of white blood cell and C reactive protein between two groups before treatment （P〉0.05）, while after treatment there had （P〈0.05）. The total effective rate of study group and control group were 73.3% and 60%, differences had statistical significance （P〈0.05）. Conclusion Linezolid in treatment of ventilator-associated pneumonia with meticillin-resistant staphylococcus aureus has curative effect.