摘要
目的观察评估使用噻托溴铵粉雾剂吸入治疗稳定期慢性阻塞性肺疾病(COPD)的临床疗效。方法选取河南省永城市人民医院2014年4月~2015年4月收治的稳定期COPD患者60例,随机分组为观察组和对照组各30例,在常规治疗基础上,观察组使用噻托溴铵粉雾剂吸入治疗,对照组使用异丙托溴铵吸入治疗,疗程均为48周,进而对比观察两组患者临床疗效。结果观察组患者治疗后各通气功能指标以及运动耐量(6 min步行距离,即6 mw D)、生活质量评估、呼吸困难指数(MMRC)等均得到明显改善,且显著优于对照组(P〈0.05),差异有统计学意义。慢性阻塞性肺病评估测试(CAT)评分明显低于对照组,差异具有显著性(P〈0.05),且不良反应发生率低。结论使用噻托溴铵粉雾剂吸入治疗COPD稳定期,能够有效改善其生活质量及肺部通气功能,心血管不良反应少,相比异丙托溴胺具有更为理想的临床疗效。
Objective To investigate and evaluate the clinical efficacy of inhaled tiotropium in treatmengt of patients with stable chronic obstructive pulmonary disease(COPD). Methods 60 patients in The People's Hospital of County from April 2014 to April 2015 with stable COPD were randomly divided into the observation group and control group, 30 in each group. On the basis of conventional treatment, the patients in the observation group received tiotropium, and the patients in the control group were treated with ipratropium bromide inhalation, both the courses of treatment were 48 weeks, and then observe clinical efficacy of two groups of patients. Results all the ventilation function index, 6-minute walk distance, the life quality scores and MMRC were significantly increased in the observation group,and the observation group improved much batter than the control group(P0.05),the difference was statistically significant. CAT score significantly lower than the control group, the difference was statistically significant(P0.05), and with a low incidence of adverse reactions. Conclusion The tiotropium powder for inhalation in the treatment of stable COPD, it can improve the quality of life and lung ventilation function effectively, it will generate much fewer cardiovascular adverse reactions and much more ideal clinical efficacy compared with ipratropium.
出处
《广东化工》
CAS
2015年第16期51-52,共2页
Guangdong Chemical Industry
基金
黄河科技学院自然科学基金(KYZR201310)
关键词
慢性阻塞性肺疾病
噻托溴铵
稳定期
chronic obstructive pulmonary disease
tiotropium
stability