P(LA-co-CA)-mPEG/DOC载药纳米粒子的制备

Preparation of P(LA-co-CA)-mPEG/DOC Drug-loaded Nanoparticles

文章以两亲聚合物P(LA-co-CA)-mPEG为载体,多西紫杉醇(DOC)为模型药物,制备P(LA-co-CA)-mPEG/DOC载药纳米粒子。考察采用直接溶解法、高密度流体技术(ASES)以及反溶剂沉淀法三种方法制备载药纳米颗粒,综合考虑粒子形貌,载药量,经济性等综合因素确定溶剂沉淀法反加法的操作来制备载药纳米颗粒是最佳方法。

Amphiphilic polymers, P（LA-co-CA）-m PEG, were used as carriers, with docetaxel（DOC, in short） as a model drug to establish a nano drug delivery system. To prepare appropriate drug-loaded nanoparticles, investigated experimental methods including direct dissolution method, a high-density fluid technology（ASES） and anti-solvent method, we chose the anti-solvent precipitation method to prepare drug-loaded nanoparticles.