血清神经元特异性烯醇化酶的含量变化与颅脑损伤程度的关系

Relationship between serum level of neuron specific enolase and degree of severity of brain injury in patients with brain injury

目的探讨血清神经元特异性烯醇化酶(NSE)的含量变化与颅脑损伤程度的关系。方法 2012年6月至2013年12月收治颅脑损伤患者254例,根据入院时GCS评分将其分为轻、中、重型三组,分别为82、88、84例;对照组为同期我院正常健康体检者85例。分别于伤后第1、3、5、7 d应用双抗体夹心酶标免疫法检测血清NSE的水平。结果轻型组患者血清NSE水平与对照组无统计学差异(P>0.05);中型组血清NSE水平明显高于轻型组(P<0.05),重型组明显高于中型组(P<0.05)。结论血清的NSE含量可在一定程度上反映脑组织的损伤程度。

Objective To investigate the relationship between the serum level of neuron specific enolase （NSE） and degree of severity of brain injury in the patients with brain injury. Methods Of 254 patients with brain injury treated in our hospital from June, 2012 to December, 2013, 82 suffered from mild brain injury, 88 from medial brain injury and 84 from severe brain injury according to GCS. The serum levels of NSE were determined by double antibody enzyme-labeled immunoassay in all the patients 1, 3, 5 and 7 days after the injury and 85 health subjects serving as control. Results The serum levels of NSE were significantly higher in the patients with severe brain injury than those in the patients with medial brain injury, which were significantly higher than those in the patients with mild brain injury 1, 3, 5 and 7 days after the injury and in the control group （P〈0.05）. There was insignificant difference in the serum levels of NSE between the patients with mild brain injury and health subjects （P〉0.05）. Conclusion It is suggested that the serum NSE level may reflect the degree of severity of brain injury in a certain extent.