内皮祖细胞与脑动脉粥样硬化的相关性研究

A Preliminary Study on the Correlation between Endothelial Progenitor Cells and Cerebral Atherosclerosis

目的探讨内皮功能紊乱的标志物（内皮祖细胞）与脑动脉粥样硬化的相关性。方法对131例患者采用流式细胞术检测外周血内皮祖细胞数量及（DSA）评估颅内外脑动脉粥样硬化程度。记录人口统计学资料和血管危险因素,并进行比较分析。结果控制混杂因素后,与对照组相比发生脑动脉粥样硬化组的内皮祖细胞水平显著降低（OR=0.344;95%CI,0.150~0.792;P=0.012）,其次,多元Logistic回归分析显示,内皮祖细胞计数与脑动脉粥样硬化的部位呈负相关。颅内动脉粥样硬化与内皮祖细胞计数无统计学意义（P〉0.05）。结论内皮祖细胞是脑动脉粥样硬化的较好独立预测因素,内皮祖细胞数量降低与脑动脉粥样硬化存在潜在的病理生理联系。

Objestlve We therefore to investigated the relationship between the level of EPCs and the severity of CAD. Methods EPCs were measured by flow cytometry. Digital subtraction angiography （DSA） was performed on 197 patients to assess intracranial and extracranial cerebral atherosclerosis. The individuals＇ demographic data, biochemical variables and vascular risk factors were col- lected in detail,compared and analyzed. Results There was a significant negative correlation between EPCs level and the preva- lence of CAD after controlling for confounders （odds ratio, OR = 0. 344; 95% CI （confidence interval）：0. 150 to 0. 7923 P = 0. 012）. Next, multivariate logistic regression showed that only EPCs count was significantly negatively associated with the location of CAD. However, EPCs were not significantly associated with intracranial atherosclerosis （ P 〉0. 05）. Cortclusion EPCs were the strong and independent predictor of the progression of cerebral atherosclerosis even after controlling for traditional risk factors. Therefore, increased EPCs might contribute to delay or prevent the occurrence and development of cerebral atherosclerosis.