膜联蛋白A2在妇产科疾病中的研究进展

Research Development of Annexin A2 in Obstetrics and Gynecology Diseases

膜联蛋白A2是一种钙离子介导的磷脂结合特性的蛋白质,属于膜联蛋白家族成员,广泛分布于胞核、胞质及细胞质膜外表面。它主要在人体内皮细胞、单核/巨噬细胞、骨髓细胞和某些肿瘤细胞中表达。膜联蛋白在细胞内参与膜形成、膜转运、胞吞、胞吐、细胞增殖、信号转导、分化及凋亡等一系列重要的生命过程。膜联蛋白A2在多种恶性肿瘤中表达异常,如在乳腺癌、胰腺癌、肝癌、结直肠癌等,在妇科肿瘤如宫颈癌、卵巢癌、子宫内膜癌中同样表达上调。现着重就膜联蛋白A2与妇产科疾病的相关性进行综述。

Annexin A2,a member of the annexin family,is a type of Ca2 ＋dependent phospholipid binding proteins. The protein has been reported to be extensively distributed in nucleus,cytoplasm,and the outer cytomembrane. In human body,Annexin A2 is mainly expressed in the endothelial cells,monocytes / macrophages,bone marrow cells and tumor cells. Annexin A2 involves in various biological processes including formation of membrane,membrane transport,endocytosis,exocytosis,cellular proliferation,signal transduction,cellular differentiation and apoptosis. Also,it is aberrantly expressed in various malignant tumors such as breast cancer,carcinoma of pancreas,hepatic carcinoma and colorectal cancer,and in patients with gynecologic neoplasms such as cervical cancer,ovarian cancer,endometrial carcinoma,Annexin A2 is up-regulated.Here is to make a review of the correlation between annexin A2 and disorders of gynecology and obstetrics.