炎症促进肿瘤发生发展的研究进展

Research Progress in Inflammation Promoting Tumor Development

炎症在肿瘤发生、发展中的作用受到广泛关注。慢性炎症或组织损伤导致的持续性炎症反应通过基因损伤或促炎性因子促进细胞转化,从而诱发慢性炎症以及肿瘤生长。在肿瘤发展的不同阶段,炎症反应发挥了决定性作用,包括肿瘤的发生、发展、恶性转化、浸润和转移等。炎症也影响了免疫监视和对治疗的反应。该文就炎症促进肿瘤发生、发展的研究进展予以综述。

Currently,the role of inflammation in tumors development has caused widespread concern.Chronic inflammation or tissue damage resulted persistent inflammation promote cell transformation through genetic damage or pro-inflammatory cytokines,and thereby induce chronic inflammation and tumor growth.Inflammatory responses play decisive roles at different stages of tumor development,including initiation,development,malignant conversion,invasion,and metastasis. Inflammation also affects the immune surveillance and response to therapy. Here reviews the research progress of inflammation promoting tumor occurrence and development.