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D-二聚体的临床应用价值 被引量:24

The Clinical Value of D-Dimer
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摘要 D-二聚体是交联纤维蛋白降解后的一种特异性产物。其水平增高提示体内凝血酶的生成及继发性纤溶系统的激活,是血栓前状态的一个敏感指标,与临床中的血栓性疾病密切相关。特别是针对肺栓塞,作为一个早期的筛查指标,具有高度的敏感性,减少了肺栓塞的误诊及漏诊。近年来,临床中发现在主动脉夹层、恶性肿瘤、急性脑梗死、心房颤动等疾病中D-二聚体水平亦有升高。对于此类疾病的早期诊断、评估治疗效果及其预后具有重要意义。 D-Dimer is a specific degradation product of cross-linked fibrin and its increased level in plasma is a biomarker indicating activation of coagulation and fibrinolysis,therefore it is a sensitive index of venous thromboembolism,especially in the pulmonary embolism( PE) for its early screening with high sensitivity,which reduces the misdiagnosis,and missed diagnosis of PE. Recently,it' s discovered that D-dimer level also increases in acute aortic dissection,cancer,acute stroke,atrial fibrillation,therefore it's also of great significance for the early diagnosis,treatment effect assessment and prognosis of these diseases.
作者 尤立蕊 唐梅
出处 《医学综述》 2015年第16期2965-2967,共3页 Medical Recapitulate
基金 国家科技支撑计划(2014BAI11B00)
关键词 肺栓塞 心血管疾病 恶性肿瘤 脑梗死 D-二聚体 临床价值 Pulmonary embolism Cardiovascular disease Cancer Cerebral infarction D-Dimer Clinical value
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