泛耐药鲍曼不动杆菌的抗菌药物治疗策略

Medication Strategy of Extensive Drug-resistant Acinetobacter Baumannii

鲍曼不动杆菌广泛存在医院环境中,是医院感染的重要条件致病菌,鲍曼不动杆菌耐药率逐年升高,临床上已出现了多重耐药、泛耐药菌株,甚至全耐药菌株。泛耐药鲍曼不动杆菌株是指仅对1~2种对其感染治疗有效的抗菌药物（主要是替加环素和/或多黏菌素）敏感的菌株,其分离率逐年上升,临床上选择抗菌药物和治疗方案非常棘手。该文就泛耐药鲍曼不动杆菌感染治疗的相关问题进行综述。

Acinetobacter baumannii is an important opportunistic pathogen and common cause of hospitalacquired infections,which is found widely existing in the environment. The resistance rate of Acinetobacter bawnannii is increasing gradually： multidrug-resistance strains,extensive drug-resistant strains,and even pan drug-resistant strains have been reported. Extensive drug-resistant Acinetobacter baumannii is sensitive only to 1-2 antibiotic drugs（ mainly tigecycline and / or polymyxins）,and the separation rate has been increasing year by year,which has become a clinical problem of anti-infective therapy. Here is to make a review of the current treatment options for extensive drug-resistant Acinetobacter baumannii infections.