急性脑梗死患者同型半胱氨酸及凝血纤溶相关指标的检验分析

Test analysis on homocysteine and blood coagulation fibrinolysis of patients with acute cerebral infarction

目的分析急性脑梗死患者同型半胱氨酸(Hcy)及凝血纤溶相关指标,以期对急性脑梗死疾病的诊疗提供借鉴。方法选取2012年4月至2014年6月入住该院脑梗死患者为研究对象,将急性脑梗死患组和非急性脑梗死患组按1∶1配对,测量两组患者的Hcy及凝血纤溶相关指标。结果非急性脑梗死组同型半胱氨酸(Hcy)、D-二聚体、组织型纤溶酶原激活剂(tPA)、纤溶酶原激活物抑制物1(PAI-1)水平明显低于急性脑梗死组;非急性脑梗死组国际标准化比值(INR)、明显高于急性脑梗死组,差异有统计学意义(P<0.05);急性脑梗死组经治疗后,进展组Hcy、D-二聚体、t-PA、PAI-1明显高于非进展组;进展组国际标准化比值(INR)、活化部分凝血活酶时间(APTT)明显低于非进展组,差异有统计学意义(P<0.05);预后良好组D-二聚体、tPA、PAI-1明显低于预后不良组,差异有统计学意义(P<0.05)。结论检测Hcy及凝血纤溶相关指标水平可有效判断急性脑梗死患者病情、预后和进展,D-二聚体水平与患者的预后相关。

Objective To analyze homocysteine in patients with acute cerebral infarction and related indicators of coagulation and fibrinolysis,diagnosis and treatment of acute cerebral infarction in order to provide reference for the disease.Methods Paitents with acute cerebral infarction from April 2012 to June 2014 were selected,they were divided into acute cerebral infarction groups and non acute cerebral infarction,,The acute cerebral infarction patients and non-patients with acute cerebral infarction group 1 ∶1.homocysteine and related indicators of coagulation and fibrinolysis were compared between two groups.Results Non-acute cerebral infarction group homocysteine（Hcy）,D-dimer,tissue-type plasminogen activator（t-PA）,plasminogen activator inhibitor-1 （PAI-1 ） levels were significantly lower than in acute cerebral infarction group;non-acute cerebral infarction group（INR）,significantly higher than the acute cerebral infarction group,the difference was statistically significant（P〈0.05）;after treatment of acute cerebral infarction group,progress group Hcy,D-dimer,t-PA,PAI-1 was significantly higher than non-progression group;progressive group of international normalized ratio （INR）,activated partial thromboplastin time（APTT）was significantly lower than non-progressive group,the difference there was statistically significant（P〈 0.05 ）;good prognosis group D-dimer,t-PA,PAI-1 were significantly lower than a poor prognosis group,the difference was statistically significant（P〈0.05）Conclusion Detection Hcy and related indicators of coagulation and fibrinolysis can effectively determine the content of the disease in patients with acute cerebral infarction, prognosis and progress,prognosis D-dimer and patients.