血清α-L-岩藻糖苷酶在妊娠胎盘功能监测中的应用

Application of serum alpha-L-fucosidase in monitoring the function of placenta

目的探讨妊娠孕妇血清α-L-岩藻糖苷酶(AFU)在妊娠胎盘功能监测中的应用。方法比较分析120例晚期胎盘功能低下、120例正常妊娠不同孕期孕妇及80例健康未孕妇女的血清AFU的变化,并对120例晚期胎盘功能孕妇血清AFU与游离雌三醇(UE3)、胎盘生乳素(HPL)进行相关性分析。结果妊娠期血清α-L-岩藻糖苷酶从孕中期开始上升,孕晚期达到高峰;胎盘功能低下孕妇的血清α-L-岩藻糖苷酶低于正常孕妇,差异有统计学意义(P<0.05),与胎盘功监测指标UE3和HPL存在一定的相关性(r分别为0.534和0.587,P<0.05)。结论 AFU可作为妊娠胎盘功能的常规生化监测指标。

Objective To investigate the application of maternal serum α-L-fucosidase to the placental function monitoring. Methods Comparative analysis of the changes of serum α-L-fucosidase between 120 patients with advanced placental dysfunction, pregnant women with different stages of gestation and 80 healthy non-pregnant woman was performed,and the correlation of the serum α-L-fucosidase of 120 cases with advanced placental dysfunction with UE3 and HPL was analyzed.Results The level of serumα-L-fucosidase of patients with placental dysfunction was lower than that of normal pregnant women,and the difference was statistically significant （P〈0.05 ）.The serum α-L-fucosidase was correlated with UE3 and HPL which were the indicators of placental function monitoring （r=0.534 and 0.587,P〈0.05）.Conclusion Serum α-L-fucosidase can serve as the conventional biochemical indicator for monitoring placental function.