不同孕期妇女甲状腺功能相关指标参考值的研究

Study of the reference intervals for thyroid-hormones in each trimester of normal pregnancy

目的了解正常妊娠妇女甲状腺激素变化,初步建立平顶山地区妊娠早、中、晚期不同孕龄孕妇甲状腺功能指标的参考值。方法选取来该院孕检的孕妇2 645例,分为早期妊娠妇女425例、中期妊娠妇女1 657例和晚期妊娠妇女563例,不同孕期再分为小于等于30岁组和大于30岁组,应用电化学发光技术检测研究对象血中游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)及甲状腺过氧化物酶抗体(TPOAb)的值。结果 FT3、FT4随着孕期增长逐渐降低,TSH和TPOAb随着孕期增长逐渐升高,且各项指标妊娠早、中、晚期小于等于30岁组和大于30岁组差异有统计学意义(P<0.05)。结论不同孕期不同年龄段的甲状腺功能指标存在差异,应加强本地区不同孕期甲状腺指标正常参考范围的研究。

Objective To survey the thyroid-hormone changes in gravidas,and to establish the reference intervals for thyroidhormones in each trimester of normal pregnancy in Pingdingshan.Methods 2 645 gravidas who established documents in our hospital were enrolled,The gravidas were divided to different groups by age （≤30 and〉30 years old）and 425 cases of early pregnancy women,1 657 cases of middle pregnancy women and 563 cases of late pregnancy women were collected as research group.4 kinds of thyroid functions in the six groups were detected by electrochemical luminescence.Results FT3 and FT4 gradually reduced as the growth of the pregnancy period,but TSH and TPOAb increased.There is statistical difference in all thyroid-hormones between all trimesters of pregnancy and different age groups.Conclusion There is significant difference in thyroid-hormones for different stages of pregnancy and different age groups.Therefore,establishing reference intervals of thyroid-hormones during different stages of pregnancy may be important for clinical practice.