原发性高血压患者血清肾素的研究

Research on serum renin in patients with primary hypertension

目的 探讨血清肾素在原发性高血压患者中的分布。方法 选择自2013年6月至2014年7月于青岛大学附属青岛市市立医院收治的130例未经药物治疗的原发性高血压患者为高血压组,其中男性100例,女性30例,平均年龄（47.32±10.26）岁。选取同期20例健康查体者作为正常对照组,其中男性16例,女性4例,平均年龄（44.85±8.18）岁。检测所有受试者血清肾素浓度。分别按照高血压分级标准、年龄、体质指数进行分组,比较肾素水平。结果 高血压组肾素水平明显低于正常对照组[（82.13±42.5）m IU/ml vs.（130.26±54.7）m IU/ml],差异有显著统计学意义（P〈0.01）。高血压2级、高血压3级较正常对照组和高血压1级降低,差异有统计学意义（P〈0.05）。根据年龄分为4组〈40岁、40~49岁、50~59岁、≥60岁,血清肾素浓度依次降低,但组间差异无统计学意义（P均〉0.05）。根据体质指数分为3组：〈24 kg/m2、24~28 kg/m2、〉28 kg/m2,肾素检测结果组间均数比较,差异均无统计学意义（P均〉0.05）。结论 原发性高血压患者血清肾素较正常体检者降低,肾素可能参与了高血压发病。

Objective To discuss the distribution of serum level of renin in patients with primary hypertension. Methods The patients with primary hypertension without drug treatment （n=130, male 100, female 30 and average age=47.32±10.26） were chosen as hypertension group, and other healthy controls （n=20 male 16, female 4 and average age=44.85±8.18） were chosen as control group from Jun. 2013 to Jul. 2014. The serum level of renin was detected in all subjects. All subjects were divided into groups according to hypertension grading criterion, ages and body mass index （BMI）, and renin level was compared. Results The serum level of renin was significantly lower in hypertension group than that in control group [（82.13±42.） mIU/mL vs. （130.26±54.7） mIU/mL, P〈0.01], and decreased in groups of hypertension grade 2 and hypertension grade 3 compared with control group and group of hypertension grade 1 （P〈0.05）. The patients were divided, according to age, into age〈40 group, age=40~49 group, age=50~59 group and age≥60 group, and the serum level of renin decreased in a descending order, but the difference had no statistical significance among groups （all P〉0.05）. The patients were divided, according to BMI, into BMI〈24 kg/m2 group, BMI=24-28 kg/m2 group and BMI〉28 kg/m2, and the comparison showed that mean difference had no statistical significance among groups （all P〉0.05）. Conclusion The serum level of renin decreases in patients with primary hypertension compared with healthy controls, while renin may participate the onset mechanism of hypertension.