miRNA在卵巢癌中作用的研究进展

The Research Progress of mi RNA in Ovarian Cancer

卵巢癌是目前死亡率最高且预后最差的妇科恶性肿瘤,缺乏有效的早期诊断方法以及化疗耐药是其主要原因。微小RNA(mi RNA)是一种内源性的非编码短序列小RNA,主要通过在转录后水平降解靶m RNA或者抑制靶基因的表达而参与调控细胞的生长、增殖和凋亡等。一些mi RNA可以通过调节体内多种癌基因和抑癌基因的表达,参与卵巢癌的发生、浸润及转移等进程;且多种特征性mi RNA在个体内的差异性表达也与卵巢癌的耐药及预后密切相关。研究与卵巢癌相关mi RNA的作用靶基因及其信号调控通路可为进一步提高卵巢癌的临床诊断与治疗提供新思路。本文主要就mi RNA在卵巢癌中作用的研究进展进行综述。

Ovarian cancer is one of gynecologic malignancies with the highest mortality and the worst prognosis. Currently, it may be mainly due to the lacking of effective methods for early diagnosis and chemotherapy resistance. Micro RNA, a short non-coding sequence of an endogenous small RNA, can get involved in regulating cell growth, proliferation and apoptosis, mainly through degrading or inhibiting the target genes at the post-transcriptional level. According to some studies, some of the tumor-associated micro RNAs play an important role in the development, invasion and metastasis of ovarian cancer by regulating the expression of a variety of oncogenes and tumor suppressor genes in vivo. Meanwhile, there is a close relationship between the differential expression of special micro RNAs and the drug resistance and prognosis of ovarian cancer. Thus, making clear of the target genes and associated regulation pathways of the ovarian cancer-related micro RNAs is of great significance for improvement of diagnosis and treatment on ovarian cancer. In this paper, we mainly reviewed the roles of micro RNAs in ovarian cancer.