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APPL1在胃癌组织中的表达及意义 被引量:2

Expression of APPL1 in gastric carcinomas and its clinical significance
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摘要 目的 探讨APPL1在胃癌组织中的表达及意义.方法 选取经手术切除的47例胃癌及23例正常胃组织,采用免疫组织化学SP法和逆转录聚合酶链式反应(RT-PCR)法检测APPL1在胃癌及正常胃组织中的表达情况.结果 APPL1基因的蛋白在胃癌组织中的表达为59.6% (28/47),正常胃组织标本组为26.1% (6/23);其mRNA在胃癌中相对表达为0.821±0.141,正常胃组织中相对表达为0.731±0.112,两者比较差异均有统计学意义(P<0.05).结论 APPL1蛋白和mR-NA在胃癌组织中表达上调,与胃癌的发生及转移有关. Objective To investigate the expression and significance of adaptor protein containing PH domain,PTB domain,and leucine zipper motif 1 (APPL1) in gastric cancers.Methods Expressions of APPL1 protein and mRNA were detected with immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR) in 47 surgical specimens of gastric carcinomas (GC) and 27 normal gastric tissue specimens,respectively.Results The expression rate of APPL1 protein was 59.6% (28/47) in GCs,and 26.1% (6/23) in normal gastric tissues,with a statistically significant difference between two groups (P <0.05).The relative expression of mRNA was 0.821 ±0.141 in GCs,and 0.731 ±0.112 in normal gastric tissues,with a statistically significant difference between two groups (P < 0.05).Conclusions The expressions of APPL1 protein and mRNA are increased in GCs,with a close relationship between GC and APPL1.
机构地区 解放军第三
出处 《中国医师杂志》 CAS 2015年第8期1157-1159,共3页 Journal of Chinese Physician
基金 国家自然科学基金资助项目(81101852)
关键词 载体蛋白质类/代谢 胃肿瘤/代谢 Carrier proteins/ME Stomach neoplasms/ME
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