痰热清注射液治疗小儿支气管肺炎的系统评价与Meta分析

Systematic evaluation and meta analysis of children bronchial pneumonia treated with tanreqing injection

目的 评价痰热清注射液治疗小儿支气管肺炎的有效性与安全性.方法 计算机检索PubMed、Ovid、CNKI和万方中英文数据库,检索时限均从2003年1月至2014年11月.按纳入与排除标准筛选文献,提取数据和评价纳入研究的方法质量后,对其方法学质量及终点指标行定性与定量合成分析.结果 共纳入13个RCT,病例共1 479例患者.Meta分析结果显示：痰热清治疗小儿支气管肺炎的治疗组与对照组相比总有效率更高[OR =2.96,95％ CI （2.22,3.96）,P＜0.01],体温恢复时间[MD=-0.53,95％ CI（-0.77,-0.29）,P＜0.01]、咳嗽消失时间[MD=-1.25,95％ CI（-2.14,-0.37）,P＜0.01]、肺部啰音消失时间[MD=-1.00,95％ CI（-1.4,-0.6）,P＜0.01]、住院时间[MD=-1.35,95％ CI（-1.83,-0.86）,P＜0.01]等指标比对照组更短,差异均有统计学意义（P＜0.05）.结论 痰热清注射液治疗小儿支气管肺炎疗效确切,能显著改善症状及体征,住院时间明显缩短,但纳入研究的方法学质量低,其疗效需更多高质量临床试验来验证.

Objective To evaluate the effectiveness and safety of tanreqing injection to children bronchial pneumonia.Methods PubMed,Ovid,CNKI,and data retrieval system of all places were searched to identify relevant studies from 2003 to November of 2014.The final documents were examined with inclusive and exclusive criteria.Results were pooled with meta-analysis on RevMan software to assess the efficacy of tanreqing injection to children bronchial pneumonia.Results The database was derived from 13 qualified studies that included a total of 1479 patients.Meta analysis showed that,compared to the control group,tanreqing injection treatment group resulted in higher effective rate [OR =2.96,95％ CI （2.22,3.96）,P ＜0.01],shorter time of recovering the normal temperature [MD----0.53,95％ CI （-0.77,-0.29）,P ＜ 0.01],shorter time of disappearance of cough [MD =-1.25,95％ CI （-2.14,-0.37）,P ＜0.01],shorter time of lungrale [MD=-1.00,95％ CI（-1.4,-0.6）,P ＜0.01],and shorter time of hospitalization time [MD =-1.35,95％ CI （-1.83,-0.86）,P ＜ 0.01].Significant difference was observed between control and treatment groups.Conclusions This study showed that tanreqing injection appeared to be more effective for children bronchial pneumonia.However,methodology showed low quality.The efficacy needs high-quality clinical trials to verify.