湖南地区成人载脂蛋白及相关指标的调查研究

Level of apolipoprotein and other related indicators in adults in Hunan province

目的 了解湖南地区成人载脂蛋白及相关指标水平及异常发生率,为建立湖南地区正常参考区间提供依据.方法 选取2014年8月至2014年10月中南大学湘雅二医院健康体检者341例,其中男239例,女102例,年龄22～77岁.按年龄分为四组,A组：22 ～42（35.56 ±5.39）岁;B组：43 ～48（45.59±1.59）岁;C组：49 ～55（51.19±1.81）岁;D组：56 ～ 77（63.08 ±5.84）岁.采用全自动生化分析仪测定载脂蛋白AI （apoAI）、载脂蛋白B（apoB）、载脂蛋白a[Lp（a）]、超敏C反应蛋白（hs-CRP）和同型半胱氨酸（HCY）.比较不同年龄以及各组不同性别间各指标水平和异常发生率的差异.结果 与男性总体水平比较,女性apoAI及Lp（a）平均水平升高（P＜0.05）,而apoB、hs-CRP及HCY均降低（P＜0.05）.四个年龄组人群的apoB和hs-CRP在总体上差异有统计学意义（P＜0.05）;各个项目的异常率差异均无统计学意义（P＞0.05）.A、B、D组女性的高HCY发生率低于男性（P＜0.05）.结论 所有指标均存在性别差异,apoAI水平随年龄改变变化不大,apoB与年龄有一定关系,Lp（a）、hs-CRP和HCY不随年龄变化而改变.男性总体HCY水平更高,且比女性更易发生高HCY血症.

Objective To investigate the levels and the abnormal incidences of apolipoprotein and other related indicators in health people in Hunan province,and to provide data for establishment of reference intervals in Hunan province.Methods The people with physical examination （n =341） were chosen from the Second Xiangya Hospital of Central South University during August 2014 ～ October 2014 （male,n =239;female,n =102） with age from 22 to 77 years old.All people were divided into 4 groups according to their age：group A aged from 22 to 42 （35.56 ± 5.39）,group B aged from 43 to 48 （45.59 ± 1.59）,group C aged from 49 to 55 （51.19 ± 1.81）,and group D aged from 56 to 77 （63.08 ±5.84）.The levels of apoAI,apoB,Lp （a）,hypersensitive C-reactive protein （hs-CRP）,and homocysteine （HCY） were detected with automatic biochemical analyzer,and were compared among different age groups and between male and female in each age group.Results Compared to male,the average levels of apoAI,and Lp （a） were significantly increased （P ＜0.05）,and apoB,hs-CRP,and Hcy were significantly decreased （P ＜ 0.05） in the female.The levels of apoB,and hs-CRP were significantly different among 4 age groups （P ＜ 0.05）.The abnormal rate in each index among 4 age groups was not significantly different （P ＞ 0.05）.For groups A,B and D,the abnormal rate of Hcy was significant higher in male relative to female （P ＜ 0.05）.Conclusions All the indices have significant difference between male and female （P ＜0.05）.The levels of apoAI,Lp （a）,hs-CRP,and Hcy do not change with the changed age.However,apoB has a certain relationship with age.The level and abnormal rate of Hcy are significantly higher in male relative to female.