不同粒径三黄粉粉体学性质及体外溶出度比较

Comparison of Micromeritics Properties and External Dissolution Rates of Sanhuang Powder with Different Particle Sizes

目的考察三黄细粉与三黄微粉的粉体学性质及体外溶出度,为其直接使用和作为中药制剂原料应用提供依据。方法对普通三黄细粉和三黄微粉的粒径分布、松密度与振实密度、休止角、吸湿性等粉体学性质进行考察和评价,采用紫外分光光度法测定二者体外溶出度并进行比较。结果三黄细粉及微粉的流动性均较差,随着粒径减小,微粉的吸湿性增强;三黄微粉较细粉的体外溶出更加迅速而充分。结论三黄微粉与三黄细粉的粉体学性质差异明显。三黄微粉的吸湿性更强,流动性欠佳,但溶出更迅速且充分,直接使用和作为中药制剂原料应用时需酌情处理。

Objective To compare the micromeritics properties and external dissolution rates of Sanhuang Powder in different particle sizes;To provide references for its direct use and application as raw materials for TCM preparation.Methods Particle size, bulk density, tap density, angle of repose, and hygroscopicity ofSanhuang micro-powder and common powder were investigated and evaluated. External dissolution rates ofSanhuang micro-powder and common powder were detected by ultraviolet spectrophotometry.Results The flowability of bothSanhuang micro-powder and common powder were not very well. With the sizes decreasing, the hygroscopicity of micro-powder became stronger. The external dissolution ofSanhuang micro-powder was more sufficient and much more quickly than common powder.Conclusion Properties ofSanhuang micro-powder and common powder are obviously different.Sanhuang micro-powder has stronger hygroscopicity and worse flowability compared with common powder. However, external dissolution ofSanhuang micro-powder is more sufficient and much more quickly than common powder. WhenSanhuang micro-powder is used directly and used as raw materials for TCM preparation, much more discretion should be considered.