高压氧配合药物治疗急性脑梗塞的临床分析

Effects of hyperbaric oxygen combined with drug therapy on acute cerebral infarction clinical analysis

目的:观察高压氧配合依达拉奉、丹参川芎嗪和奥扎格雷纳治疗急性脑梗塞患者的临床疗效。方法:将200例急性脑梗塞患者随机分为观察组和对照组各100例。对照组采用依达拉奉、丹参川芎嗪和奥扎格雷纳联合治疗,观察组在对照组治疗的基础上配合高压氧治疗。10d一疗程,三个疗程后,对两组治疗前后神经功能缺损评分;日常生活活动能力(ADL)评分及临床疗效进行比较。结果:治疗三个疗程后,观察组总有效率明显高于对照组,差异有统计学意义(P<0.05);观察组治疗后日常生活活动能力(ADL)评分明显高于对照组,差异有统计学意义(P<0.05)。观察组治疗后神经功能缺损评分明显低于对照组,差异有统计学意义(P<0.05);结论:高压氧配合依达拉奉、丹参川芎嗪和奥扎格雷纳治疗急性脑梗塞可以改善微循环及神经功能缺损症状,提高患者的生活质量。

Objective： To explore the effects of hyperbaric oxygen combined with edaravone, salviae miltiorrhizae and ligustrazine and sodium ozagrel on acute cerebral infarction clinical analysis. Methods： A total of 200 cases of acute cerebral in- fraction patients were randomly divided into observation group and control group with 100 patients in each group. The control group was treated with edaravone, salvia miltiorrhizae and ligustrazine and sodium ozagrel. Based on treatments of control group, the observation group was also given hyperbaric oxygen therapy. After 3 treatment courses （10 days for a course of treatment）, the neurological deficit scores were observed before and after treatment for comparison, meanwhile the activities of daily living （ADL） and clinical effects were compared. Results： After 3 courses of treatment, the total effective rate of the ob- servation group （92 %） was significantly higher than that of the control group （79 %） （P〈 0.05）. After treatment, the score of ADL in observation group was obviously higher than that of the control group （P〈0.05）. After treatment, the neurological deficit scores of the observation group were obviously lower than that of the control group （P〈 0.05）. Conclusion： Hyperbaric oxygen combined with edaravone, salvia miltiorrhizae and ligustrazine and sodium ozagrel can improve symptoms of mierocireu-lation and neurologic impairment for patients with acute cerebral infarction, it can also improve patients life quality.