摘要
目的探讨多囊卵巢综合症(PCOS)患者血清硫酸脱氢表雄酮(DHEAS)及总睾酮(TT)与血脂异常的关系。方法选择在我院就诊的未经过药物治疗的PCOS患者219例,分别检测其血清DHEAS、TT及血脂相关指标,并对其进行统计分析。结果 TT高值组的BMI、DHEAS、CHOL、LDL-C及Apo B明显高于TT低值组,具有统计学意义(P<0.05)。DHEAS高值组的Apo A I明显高于DHEAS低值组,具有统计学意义(P<0.05)。血清TT水平与BMI、DHEAS、CHOL、LDL-C及Apo B正相关,而与年龄负相关,具有统计学意义(P<0.05)。DHEAS水平与TT、HDL-C及Apo A I正相关,而与Apo B负相关,具有统计学意义(P<0.05)。结论高水平DHEAS常与较好的脂类代谢参数相关联,而恰恰相反,高水平TT常与较差的脂类代谢参数相关联。在预测PCOS患者发生血脂异常及冠心病的危险时,要区分不同来源的雄激素的不同意义。
Objective To study the association of endocrine dehydroepiandrosterone sulfate（ DHEAS） and total testosterone（ TT） parameters with dyslipidemia in women with polycystic ovary syndrome（ PCOS）. Methods Two hundred and nineteen untreated women with PCOS were enrolled. The levels of serum DHEAS,TT and lipid profiles were measured and the results were analyzed statistically. Results The BMI,DHEAS,total cholesterol（ CHOL）,low-density lipoprotein（ LDL-C） and apolipoprotein-B（ Apo B） levels in the higher TT Group were significantly higher than that of the lower TT group（P〈0. 05）. The apolipoprotein-A（ Apo A I） level was significantly higher in the higher DHEAS Group compared with the lower DHEAS group（P〈0. 05）. The TT level was positively correlated with the BMI,DHEAS,CHOL,LDL-C and Apo B levels,but inversely related to age（P〈0. 05）. The DHEAS level was positively correlated with the TT,HDL-C and Apo A I levels,but inversely related to Apo B level（P〈0. 05）. Conclusion The results suggest high DHEAS level was associated with better lipid profiles,whereas high TT level was associated with poor lipid profiles. It is important to make a distinction between adrenal and ovarian hyperandrogenism when evaluating dyslipidemia and coronary heart disease in PCOS.
出处
《标记免疫分析与临床》
CAS
2015年第8期711-714,共4页
Labeled Immunoassays and Clinical Medicine
基金
首都医科大学附属北京妇产医院院内课题(2013-13)
