STD门诊患者沙眼衣原体、解脲支原体、淋球菌与人乳头瘤病毒感染情况分析

Analysis of Chlamydia Trachomatis,Ureaplasma Urealyticum,Neisseria Gonorrhoeae and Human Papillomavirus Infections in STD Cases

目的了解本地区STD门诊患者沙眼衣原体(CT)、解脲支原体(UU)、淋球菌(NG)与人乳头瘤病毒(HPV)感染情况,从而指导临床诊断与用药。方法采用聚合酶链式反应(PCR)结合Taqman技术,对采集自来院就诊STD门诊患者的女性宫颈口分泌物、男性尿道口分泌物及相关尿液标本中的特异性DNA核酸片段进行荧光PCR检测。结果 CT、UU、NG、HPV四种病原体总感染率分别为7.49%、42.92%、3.11%和3.06%,除HPV外其它三种病原菌感染率存在性别差异;其中以UU感染率居首位,女性明显高于男性;二重感染率为5.76%,三重感染率为0.83%,未见四重感染,其中以CT和UU二重感染最常见;不同年龄段感染情况显示,以40岁以下年龄段感染率最高。结论将HPV纳入泌尿生殖感染检测很重要;通过本研究也发现,无论单一病原体感染还是混合感染,除HPV外均存在明显的性别分布差异,而且两种感染的性别分布相一致;40岁以下年龄段为主要传染源和高危人群,应作为性传播疾病防治工作的重点;双重感染和三重感染较常见,应引起高度重视;目前未发现四重感染。

Objective To discuss the infection status of chlamydia trachomatis（ CT）,ureaplasma urealyticum（ UU）,neisseria gonorrhoeae（ NG） and human papillomavirus（ HPV） infections in sexually transmitted disease（ STD） cases.Methods The CT,UU,NG and HPV levels of STD male and female patients were detected by fluorescence quantitative polymerase chain reaction（ PCR） combined with Taqman technology. Results The infection rates of CT,UU,NG and HPV were 7. 49%,42. 92%,3. 11% and 3. 06% respectively. The HPV infection showed a obvious gender differences. The UU positive rate was the highest and that in woman was significantly higher than that of in man. The super infection rate was 5. 76%,the triple infection rate was 0. 83%,and no fourfold infection. The CT and UU super infection was most commonly cases. The results showed infection rate in ages below 40 years old was the highest. Conclusion It is important to incorporate HPV to the detection of urogenital infections. With obvious gender differences in addition to HPV whether single and mixed infection,and it is consistent with the distribution of both infections. The age below 40 years group is the main source of infection and the high risk population,and should be considered as focus on sexually transmitted disease prevention. The super and triple infection are common,no fourfold infection,and people should pay more attention.