肺炎支原体抗体联合超敏C反应蛋白检测在小儿支原体肺炎感染诊断中的临床价值

Clinical Value of Combined Detection of Mycoplasma Pneumoniae Antibody and C Reactive Protein in Diagnosis of Children with Mycoplasma Pneumoniae Pneumonia

目的调查研究小儿支原体肺炎感染患者肺炎支原体抗体(MP-Ab)及超敏C反应蛋白(hs-CRP)水平的变化,探讨肺炎支原体抗体与超敏C反应蛋白联合检测对小儿支原体肺炎感染的临床诊断价值。方法肺炎支原体肺炎患儿110例,对照儿童120例,均按照《诸福棠实用儿科学》中支原体肺炎诊断标准确诊,两组分别进行MP-Ab、hs-CRP检测,肺炎支原体抗体判定以MP-Ab滴度≥1∶160为阳性,超敏C反应蛋白判定以hs-CRP>5mg/L为阳性。通过分析MP-Ab检测法与MP-Ab联合hs-CRP检测法敏感性、特异性差异,探讨MP-Ab联合hs-CRP检测法诊断小儿支原体肺炎感染的临床意义。结果肺炎支原体肺炎患儿组MP-Ab滴度≥1∶160比率高于正常对照组,肺炎支原体肺炎患儿组hs-CRP高于正常对照组,差异均有统计学意义(P<0.05);MP-Ab检测法诊断肺炎支原体肺炎的灵敏度为78.2%,MP-Ab联合hs-CRP检测法诊断肺炎支原体肺炎的灵敏度为89.1%,MP-Ab联合hs-CRP检测肺炎支原体肺炎的灵敏度高于MP-Ab检测法,差异有统计学意义(P<0.05);MP-Ab检测法诊断肺炎支原体肺炎的特异度为94.2%,MP-Ab联合hs-CRP检测法诊断肺炎支原体肺炎的特异度为89.2%,差异无统计学意义(P>0.05)。结论 MP-Ab与hs-CRP联合检测能提高小儿支原体肺炎感染的诊断率,具有较高临床价值。

Objective To investigate the changes of mycoplasma pneumoniae antibody（ MP-Ab） and high sensitive C reactive protein（ CRP） and their clinical values in the diagnosis of children with mycoplasma pneumonia infection. Methods 110 cases of children with Mycoplasma pneumoniae pneumonia and 120 cases of normal controls children were selected into this study. The MP-Ab and hs CRP levels were detected and MP-Ab titers greater than or equal to 1： 160 and hs-CRP 5mg / L were regarded as positive samples. Results The positive rate of MP-Ab and the hs-CRP levels in children with Mycoplasma pneumoniae pneumonia were significantly higher than that of normal controls（P〈0. 05）. The sensitivity of MP-Ab assay for the diagnosis of mycoplasma pneumonia was 78. 2%. The sensitivity of MP-Ab combined with hs-CRP assay for the diagnosis of mycoplasma pneumonia was 89. 1%,higher than that of MP-Ab detection alone（P〈0. 05）. The specificity of MP-Ab assay alone and combined with hs-CRP assay for the diagnosis of Mycoplasma pneumoniae pneumonia were 94. 2% and 89. 2% respectively and no statistically significant beteen them（P〈0. 05）. Conclusion The combined detection of MP-Ab and hs-CRP could have a high clinical value and improve the diagnosis rate of mycoplasma pneumonia in children.