血清PCT和CRP检测在社区获得性肺炎诊断中的临床意义

Clinical Significance of Detection of Serum PCT and CRP in Diagnosis of Community Acquired Pneumonia

目的探讨血清降钙素原(PCT)和C反应蛋白(CRP)在社区获得性肺炎(CAP)实验室诊断中的应用价值。方法分析我院2014年1月至2015年1月社区获得性肺炎患者150例。并选取同期健康体检者150例做为正常对照组。所有各组均进行血清PCT和CRP含量的测定。结果社区获得性肺炎患者组的血清PCT和CRP含量明显高于正常对照组,相比较有统计学意义(P<0.05);PCT和CRP的敏感性分别为87.3%和83.3%,二者敏感性比较差异无统计学意义(P>0.05);但二者的特异度相比较,PCT为95.3%,较CRP的70.7%高,相比较有统计学意义(P<0.05)。结论血清PCT和CRP的测定在诊断CAP中都有一定的应用价值,特别是PCT在敏感性和特异性方面都优于CRP,是一个较好的诊断与鉴别诊断的指标,更值得临床推广应用。

Objective To explore the value of serum procalcitonin（ PCT） and C reactive protein（ CRP） detection in the diagnosis of community acquired pneumonia（ CAP）. Methods The serum PCT and CRP levels in 150 cases of CAP patients and 150 healthy subjects were determined. Results The serum PCT and CRP contents in patients with CAP were significantly higher than that in the normal controls（P〈0. 05）. The sensitivity of PCT and CRP were 87. 3%and 83. 3% without significant differences（P〈0. 05）; but the specificity of PCT and CRP were 95. 3% and CRP70. 7% with significant differences（P〈0. 05）. Conclusion The serum PCT and CRP determination has certain application value in the diagnosis of CAP. The serum PCT has superior sensitivity and specificity,and might be a better index in the differential diagnosis of community acquired pneumonia.