辅助性T细胞17/调节性T细胞免疫失衡与子痫前期相关性的研究进展

Research progress of relationship between helper T cell 17/regulatory T cell immune imbalance and pre-eclampsia

子痫前期(PE)是妊娠期特发性疾病,目前我国PE发病率为9.4%,其病因和发病机制尚未阐明。近年来研究结果提示PE的发生、发展与母-胎免疫耐受失衡有关,母体免疫系统不能识别胎儿的同种异型抗原,导致异常免疫系统激活,从而可能在PE的发病机制中起主导作用。PE患者存在辅助性T细胞(Th)1/Th2失衡,Th17/调节性T细胞(regulatory T cell,Treg)免疫失衡也参与其中,并且向Th17免疫偏移。笔者拟就近年来Th17/Treg免疫失衡与PE相关性的最新研究进展进行综述如下。

Pre-eclampsia（PE）is a common obstetric syndrome affecting about 9.4% of pregnant women in our country.The etiology and pathogenesis of PE are not fully understood.Some literatures found that the onset of PE was an imbalance of maternal-fetal immune tolerance.Maternal immune system can not recognize the fetal alloantigen and the activation of cell-mediated immunity which may play a role in the etiology of PE.PE has an immune imbalance of helper T cell（Th）1/Th2.Recent data suggest that PE is a Th17/regulatory T cell（Treg）immune imbalance with a predominance of Th17 immunity.The latest research progress about relationship between Th17/Treg immune imbalance and PE will be reviewed.