骨桥蛋白和CD44v6在恶性黑素瘤中的表达及其意义

Expression and significance of osteopontin and CD44v6 in malignant melanoma

目的:探讨骨桥蛋白(OPN)和CD44v6在恶性黑素瘤中的表达特点及其生物学意义。方法:应用免疫组化法分别检测16例恶性黑素瘤患者皮损及12例良性黑素痣中OPN和CD44v6的表达情况。结果:OPN和CD44v6在恶性黑素瘤中阳性表达分别为87.5%%和75%,显著高于良性黑素痣的16.7%和0(P<0.01)。OPN和CD44v6呈正相关关系(r=0.69,P<0.05)。恶性黑素瘤中OPN和CD44v6阳性表达可能与其高转移性能有关(P<0.05)。结论:OPN和CD44v6的高表达在恶性黑素瘤的发生和转移中可能起着重要的协同作用。

Objective To study the expression and biological significance of osteopont!n（OPN）and CD44v6 in human malignant melanoma. Methods The distribution and expression of ~PN and CD44v6 was detected in 16 malignant melanoma patients and in 12 patients with benign melanocytic nevi by immunohistochemistry. Results The positive expression rates of OPN and CD44v6 in malignant melanoma were 87.5% and 75% ,respectively.The expression of OPN and CD44v6 was significantly higher in malignant melanoma than that in benign melanocytic nevi tissues（P〈0.01））. There was a positive correlation between OPN and CD44v6（r=-0.69,P〈0.05）.The positive rates of OPN and CD44v6 were associated with metastasis（P〈0.05）. Conclusion Overexpression of OPN and CD44v6 may contribute to the development and metastasis of malignant melanoma.