宫颈癌组织中高危型HPV与Ki-67表达的相关性

Expressions of High-risk HPV and Ki-67 in the Cervical Cancer and Their Correlation

目的分析高危型人乳头瘤病毒(HPV)与Ki-67在宫颈癌组织中表达的相关性。方法入组行手术切除并经病理证实的60例宫颈鳞癌组织标本及60例正常宫颈组织标本,分别检测HPV16及Ki-67表达水平,并分析两者的相关性。结果宫颈鳞癌组织中Ki-67阳性率为81.7%,高于正常宫颈组织的20.0%,差异有统计学意义(P<0.05)。宫颈鳞癌组织中HPV16阳性率为71.7%,高于正常宫颈组织的5.0%,差异有统计学意义(P<0.05)。HPV16与Ki-67在宫颈鳞癌组织中的表达呈正相关(r=0.413,P<0.05)。结论宫颈癌组织中高危型HPV感染率较高,Ki-67表达水平也升高,且两者的表达趋势一致。

Objective To analyze the expressions of high-risk human papilloma virus （HPV） and Ki-67 in cer- vical cancer and their correlation. Methods Sixty cases of cervical squamous cell cancer and 60 cases of normal cervical tissues confirmed by pathology were selected. The expressions of high-risk HPV and Ki-67 were detected and their correlation was statistically analyzed. Results The positive rates in the cervical squamous cell cancer and the normal cervical tissues were 81.7% and 20.0% respectively （P 〈 0.05） ; the positive rates of HPV16 were 71.7% and 5.0% respectively （P 〈 0.05 ）. There was a positive correlation between HPV16 and Ki-67 （r = 0.413 ,P 〈0.05 ）. Conclusion Both the infection rate of high-risk HPV and the expression level of Ki-67 were higher in the cervical cancer, and there is a positive correlation.