爵床煎剂对小鼠镇痛抗炎作用初探

PRELIMINARY STUDY ON THE ANALGESIC AND ANTI-INFLAMMATORY EFFECTS OF ROSTELLULARIA PROCUMBENS DECOCTION IN MICE

目的探讨爵床的镇痛、抗炎作用。方法采用热板法、扭体法致痛,观察高、中、低剂量爵床水煎剂的镇痛作用;采用耳肿法、足肿法致炎,观察高、中、低剂量爵床水煎剂的抗炎作用。结果爵床水煎剂高、中、低剂量对热板法所致小鼠痛阈值有明显的提高,与生理盐水对照组比较差异极显著(P<0.01);爵床水煎剂高、中剂量给药后与自身给药前比较,差异显著(P<0.01),爵床水煎剂低剂量给药后15、30、60 min与给药前比较差异显著(P<0.01);爵床水煎剂高、中、低剂量对醋酸所致扭体反应数均有明显抑制作用,与生理盐水对照组比较差异显著(P<0.01)。爵床水煎剂高、中、低剂量对二甲苯所致小鼠耳廓肿胀均有明显抑制作用,与生理盐水对照组比较差异显著(P<0.01,P<0.05);爵床水煎剂高、中、低剂量对蛋清所致小鼠足跖肿胀均有明显抑制作用,与生理盐水对照组比较差异极显著(P<0.01)。结论爵床水煎剂具有一定镇痛、抗炎作用。

Objective：To investigate the analgesic and anti-inflammatory effects ofRostellularia procumbens in mice. Methods：Byusing the hot-plate and acetic acid writhing method to induce pain in mice, and observe the analgesic effect of different doses ofR. procumbensdecoction. Byusing the ear tumefaction, foot swelling to induce inflammation in mice, and observe the anti-inflammatory effect of different decoction doses.Results： Different doses ofR. procumbensdecoction could significantly elevate the pain threshold with hot plate method （P 〈 0.01）, comparing with the saline control group. High, medium decoction dosesandlow-dose for 15, 30, 60 min could significantly elevate the pain threshold with hot plate method （P 〈 0.01）, comparing with the self-administration earlier. Compared with the saline control group, the decoction could significantly reduce the number with acetic acid writhing method, restrain mouse ear tumefaction caused by xylene and mouse foot swelling caused by egg white （P 〈 0.01）.Conclusion：The results showsR. procumbens decoction has the analgesic effects and anti-inflammatory.