循环肿瘤细胞的形成机制及其在Ⅰ-Ⅲ期结直肠癌中的应用进展

Formation mechanism of circulating tumor cells and progress of its application in stage colorectal carcinoma

结直肠癌术后高复发率及致死率一直是困扰临床医师的问题。循环肿瘤细胞（CTC）检测技术是一种易获取性、可重复性、相对无创性的新型“液体活检”技术，能帮助我们实时检测机体肿瘤状态，提示结直肠癌复发及预后相关信息。本文阐述CTC形成的机制及相关主要调控分子，同时比较不同CTC检测技术的原理及优缺点，探讨CTC在Ⅰ-Ⅲ期结直肠中相关应用及临床价值，探索解决CTC低检出率的方法。

It has been a problem in clinical practice that high recurrence and poor survival of patients with colorectal cancer undergoing surgery. As an easy-accessible, repetitive, non-invasive “liquid biopsy”technology, circulating tumor cells （CTC） can assist us in many fields, for instance, real-time monitoring tumor status and providing information about recurrence and prognosis of colorectal cancer. In this review , generation mechanism and relevant major regulation molecules of CTC will be elucidated, and principles, superiorities and inferiorities among different detection technologies were compared. Besides, clinical application and prognostic value of CTC in stage Ⅰ-Ⅲ colorectal caner were discussed, and the dilemma of low detection rate of CTC will be tried to solve as well.