含复方尿囊素四联疗法治疗幽门螺杆菌感染慢性胃炎的疗效

Curative effects of quadruple therapy containing compound allantoin in the treatment of chronic gastritis infected with helicobacter pylori

目的探讨含复方尿囊素四联疗法在幽门螺杆菌感染慢性胃炎治疗中的临床疗效。方法选取本院2011年1月~2012年12月间90例幽门螺杆菌感染的慢性胃炎患者为研究对象,将其按照随机数字表法分为研究组与对照组,对照组给予常规含铋剂四联疗法治疗,研究组给予含复方尿囊素四联疗法治疗,观察两组的临床治疗效果。结果研究组患者的临床治疗有效率、幽门螺杆菌转阴率分别为91.1%、86.7%,与对照组的88.9%、82.2%比较差异无统计学意义（P〉0.05）;研究组不良反应发生率6.7%,低于对照组的22.2%,两组比较差异有统计学意义（P〈0.05）。研究组患者对药物耐受程度明显高于对照组,差异有统计学有意义（P〈0.05）。结论临床中应用含复方尿囊素四联疗法治疗幽门螺杆菌感染慢性胃炎是可行的,能够有效的降低不良反应,提高药物耐受力,值得在临床中应用。

Objective To explore the clinical effects of quadruple therapy containing compound allantoin in the treat- ment of chronic gastritis infected with helicobacter pylori. Methods A total of 90 patients with chronic gastritis infected with helicobacter pylori in our hospital from January 2011 to December 2012 were selected as research subjects. They were assigned to research group and control group according to the method of random number table. The control group was given regular quadruple therapy containing bismuth, and the research group was given quadruple therapy contain- ing compound allantoin. Clinical curative effects in the two groups were observed. Results The effective rate of clinical treatment and negative conversion rate of helicobacter pylori in the research group were 91.1% and 86.7%, and the dif- ferences compared with those of 88.9% and 82.2% in the control group were not statistically significant （P〉0.05）; inci- dence of adverse effects in the research group was 6.7%, lower than that of 22.2% in the control group, and the differ- ence was statistically significant between the two groups （P〈0.05）. Drug tolerance degree in the research group was significantly higher than that in the control group （P〈0.05）, and the difference was statistically significant. Conclu- sion Clinical application of quadruple therapy containing compound allantoin in the treatment of chronic gastritis in- fected with helieobacter pylori is feasible. It is able to effectively reduce adverse effects, improve drug tolerance and is worthy of clinical application.