硫酸羟氯喹联合他克莫司治疗口腔扁平苔藓的疗效研究

A study on the curative effects of hydroxychloroquine sulphate combined with tacrolimus in the treatment of oral lichen planus

目的观察传统免疫抑制剂(硫酸羟氯喹)联合他克莫司治疗口腔扁平苔藓的短期疗效和安全性。方法80例口腔扁平苔藓患者分为两组,实验组给予0.0015%他克莫司溶液每日2次含服及口服硫酸羟氯喹片100 mg,每日1次,对照组予口服硫酸羟氯喹片100 mg,每日1次,治疗观察4周,治疗结束时评价有效率和不良反应发生率。结果实验组治疗有效率为95.0%,对照组治疗有效率为35.0%,硫酸羟氯喹联合他克莫司对口腔扁平苔藓的短期疗效明显优于硫酸羟氯喹(χ2=31.65,P=0.00),但两组不良反应率无明显差异。结论硫酸羟氯喹联合他克莫司对口腔扁平苔藓的短期疗效明显优于硫酸羟氯喹,安全有效,值得临床推广应用。

Objective To observe the short-term curative effects and safety of conventional immunosuppressor （hydrox- ychloroquine sulphate） combined with taerolimus in the treatment of oral lichen planus. Methods Eighty patients with oral lichen planus ~ere assigned to two groups. The experiment group was sublingually given 0.0015% of tacrolimus so- lution twice a day, ~and was orally given 100 mg of hydroxychloroquine sulphate tablets once a day. The control group was orally given 100 mg of hydroxychloroquine sulphate tablets once a day. The treatment was observed for 4 weeks, and the effective rate and incidence of adverse effects at the end of the treatment were evaluated. Results The effective rate of experiment group was 95.0%, and the control group was 35.0%. The short-term curative effect of hydroxychloro- quine sulphate combined with tacrolimus in the treatment of oral lichen planus was significantly better than that of hydroxyehloroquine sulphate alone （X2=31.65, P=0.00）, but the incidence of adverse had not significantly different be- tween two groups. Conclusion The short-term curative effect of hydroxyehloroquine sulphate combined with tacrolimus in the treatment of oral lichen planus is significantly better than that of hydroxychloroquine sulphate alone, which is safe and effective, and is worthy of clinical promotion and application.