重组牛碱性成纤维细胞生长因子治疗喉癌患者放射性皮炎的观察与护理

Observation of recombinant bovine basic fibroblast growth factor in the treatment of radiodermatitis in patients with laryngeal cancer and their nursing care

目的探讨重组牛碱性成纤维细胞生长因子外用溶液在喉癌放疗患者中的应用价值,并观察喉癌放疗患者耐受性、放射性皮炎发生率及生活质量。方法采用完全随机数学表法将46例喉癌放疗患者分为对照组和观察组,各23例。对照组给予放射治疗后的综合护理干预,试验组在综合护理的基础上给予重组牛碱性成纤维细胞生长因子外用溶液喷射颈部,比较两组干预后的放疗耐受性、放射性皮炎发生率和生活质量。结果试验组放疗耐受性明显优于对照组,重度放射性皮炎发生率明显低于对照组,差异均有统计学意义(P<0.05);试验组的放疗生活质量明显优于对照组,差异有统计学意义(P<0.05)。结论喉癌放疗患者给予重组牛碱性成纤维细胞生长因子外用溶液不仅可增加放疗的耐受性,减少重度放射性皮炎的发生率,促进放疗后局部皮肤的愈合,还能提高患者的生活质量。

Objective To explore the application value of in-vitro use solution of recombinant bovine basic fibroblast growth factor in patients with laryngeal cancer under radiotherapy, and to observe the tolerability, incidence rate of ra- diodermatitis and life quality between two groups of patients with laryngeal cancer under radiotherapy. Methods All 46 patients with laryngeal cancer under radiotherapy were assigned to control group and observation group according to the method of complete random number table, with 23 patients in each group. The control group was given comprehensive nursing intervention after radiotherapy, and the experiment group was given in-vitro solution of recombinant bovine ba- sic fibroblast growth factor sprayed onto the neck on the basis of comprehensive nursing. Tolerability of radiotherapy, incidence of radiodermatitis and life quality between both groups after the intervention were compared. Results Tolera- bility of radiotherapy in the experiment group was significantly better than that in the control group, and the incidence of severe radiodermatitis was significantly lower than that in the control group. The differences were all statistically significant （/~〈0.05） ; life quality during radiotherapy in the experiment group was significantly better than that in the control group, and the difference was statistically significant （P〈0.05）. Conclusion In-vitro use solution of recombinant bovine basic fibroblast growth factor applied in patients with laryngeal cancer under radiotherapy not only increases the tolerability of radiotherapy, reduces the incidence of severe radiodermatitis, and promotes the healing of local skins after radiotherapy, but also improves patients＂ life quality.