急性胰腺炎凝血功能变化及临床意义

Significance and change of coagulation function in patients with acute pancreatitis

目的探讨急性胰腺炎凝血功能变化及临床意义。方法回顾性分析在我院进行治疗的急性胰腺炎患者80例的临床资料,根据患者病情分为轻症组46例、重症组34例。入院后检测凝血功能相关指标,并分析其与APACHEⅡ评分的相关性。结果轻症组PT、APTT、FIB、D-D水平与对照组比较差异无统计学意义(P>0.05)。重症组PT、APTT、FIB、D-D水平均显著高于对照组和轻症组(P<0.01)。MODS组患者凝血功能指标均显著高于MODS组(P<0.05或P<0.01)。FIB和D-D与重症患者APACHEⅡ评分呈正相关(r=0.78,0.82,P<0.01)。结论轻症胰腺炎患者凝血功能基本正常,而重症胰腺炎患者出现凝血功能障碍,FIB和D-D与患者病情指标APACHEⅡ具有相关性。

Objective To discuss significance and change of coagulation function in patients with acute pancreatitis. Methods Clinical data of 80 cases with acute pancreatitis were analyzed. 46 cases were mild acute pancreatitis as MAP group. 34 cases were severe acute pancreatitis as SAP group. Coagulation function index were detected and association between coagulation function index and APACHE Ⅱ. Results Levels of PT, APTY, FIB, D-D of MAP group showed no significant differece compared to control group （P〉0.05）. Levels of PT, AprⅡ, FIB, D-D of SAP group were higher than those of MAP group and control gorup（P〈0.01）. The coagulation function index of MODS group were significantly high- er than MODS group （P〈0.05 or P〈0.01）. Levels of FIB and D-D showed association with APACHE Ⅱ （r=0.78, 0.82, P〈0.01）. Conclusion Coagulation function in patients with MAP is normal, which is abnormal in patients with SAP. Lev els of FIB and D-D show association with APACHE Ⅱ.