抗核抗体滴度水平与肝功能损害的相关性探讨

The correlation between ANA level and liver function damage

目的探讨不同滴度的抗核抗体(ANA)与抗核抗体谱的相关性及其与肝功能异常检出率的临床意义。方法将78例ANA阳性患者根据结果滴度分为A组1∶100、B组1∶320和C组1∶1000。ANA定性检测采用免疫荧光法;抗核抗体谱检测采用免疫印迹法;ALT、AST、GGT采用速率法检测;TP采用双缩脲法检测。结果各滴度ANA阳性患者中ENA阳性检出率分别为A组63.33%、B组74.07%、C组80.95%。肝功能异常检出率分别为20.00%、29.60%、47.60%。结论 ANA阳性患者肝功能损害检出率高,随着ANA滴度的升高肝功能损害检出率也升高;ANA阳性与肝功能损伤有相关性。

Objective To investigate correlation of the ANA and antinuclear antibody spectrum, and clinical significance of the abnormal liver function rate. Methods A total of 78 cases of ANA positive were divided into group A （1：100）, group B（1：320） and group C（1：1000）. ANA qualitative detection by immunofluorescence method; Antinuclear antibody spectrum detection using western blot method; ALT, AST, GGT were detected by the rate method; Biuret method was used to test TP. Results ENA positive detection rate were group A（63.33%）, group B（74.07%）, group C（80.95%）. The abnormal liver function rate was 20.00%, 29.60%, 47.60%. Conclusion Liver function abnormalities in patients with ANA positive rate is increased, abnormal liver function rate is also increased, so ANA is associated with the abnormal liver function.