酚妥拉明联合多巴胺对重症肺炎患者血清炎症因子的影响

EFFECT OF PHENTOLAMINE COMBINED WITH DOPAMINE ON SERUM INFLAMMATORY FACTORS IN PATIENTS WITH SEVERE PNEUMONIA

目的探讨酚妥拉明联合多巴胺治疗重症肺炎的疗效及对患者血清炎症因子影响。方法重症肺炎患者98例,随机分成对照组和观察组,各49例。对照组接受重症肺炎的常规对症治疗。观察组在对照组常规对症治疗方式的基础上,加用酚妥拉明联合多巴胺治疗。结果观察组总有效率为91.84%高于对照组总有效率75.51%,差异具有统计学意义(P<0.01)。观察组气喘症状消失时间(2.05±0.88)d、肺啰音症状消失时间(4.35±1.26)d、咳嗽症状消失时间(4.54±1.15)d、住院天数(2.32±1.14)d均少于对照组气喘症状消失时间(3.86±1.30)d、肺啰音症状消失时间(6.50±1.13)d、咳嗽症状消失时间(6.65±1.33)d、住院天数(3.31±1.56)d,二组比较差异均有统计学意义(P<0.01)。治疗后,观察组血清IL-6(45.95±5.93)pg/mL、IL-8(9.55±4.41)pg/mL、CRP(16.08±5.18)mg/L、TNF-α(16.18±5.38)μg/mL均低于对照组血清IL-6(58.60±6.75)pg/mL、IL-8(18.75±5.49)pg/mL、CRP(22.45±5.56)mg/L、TNF-α(22.45±5.64)μg/mL,差异均有统计学意义(P<0.01)。治疗后,观察组重症肺炎患者CD3+、CD4+指标高于对照组重症肺炎患者CD3+、CD4+指标,差异有统计学意义(P<0.05)。治疗后,观察组重症肺炎患者CD8+指标低于对照组重症肺炎患者CD8+指标,差异有统计学意义(P<0.01)。结论酚妥拉明联合多巴胺治疗重症肺炎疗效显著,能够改善患者症状体征、并能改善患者的免疫功能。

Objective To evaluate the clinical efficacy of Phentolamine combined with Dopamine in the treatment of severe pneumonia and its influence on the serum inflammatory factors of the patients. Methods A total of 98 patients with severe pneumonia were randomly divided into the control group and the obser- vation group, each with 49 cases. Patients in the control group received conventional symptomatic treat- ment, whereas those in the observation group were given conventional symptomatic treatment plus Phento- lamine combined with Dopamine for treatment. Results The total effective rate in the observation group was 91.84%, higher than that in the control group, which was 75. 51%, and the differerme was statistical- ly significant （P〈0.01）. The time consumed for the disappearance of the symptoms of asthma, pulmonary tales and cough, and the hospital stay in the observation group were （2.05 ± 0. 88}d, （4. 35 ± 1.26）d, （4.54 ± 1.15）d, and （2.32 ± 1.14）d, respectively, less than those in the control group, which were （3.86 ± 1.30）d, （6. 50 ± 1. 13）d, （6.65± 1.33）d, and （3.31 ± 1. 56）d, respectively, and the differences were statistically significant （P〈0.01）. After treatment, the serum IL - 6, IL - 8, CRP, and TNF - α in the observation group were （45.95 ± 593 ） pg/ml, （955 ±4. 41 ） pg/ml, （ 16.08 ± 5.18 ） rag/L, and （ 16. 18 ± 5; 38）g/ml, respectively, lower than those in the control group, which were （5.86 ± 675）pg/ml, （18.75 ± 5.49）pg/mll （ 22.45 ± 5.56）mg/L, and （22.45± 564）g/ml, respectively, with the differences being statistically significant （P〈0.01）. After treatment, the index of CD3 ＋ and CD4 ＋ in the ohservation group were significantly higher than the control group, but the index of CD8 ＋ in the observation group was lower than the control group, the differences were statistically significant （P〈0.05）. Conclusion The combined therapy of Phentolamine and Dopamine is with significant curative effect in the treatment of severe pneumonia, which can improve the symptoms and immune function of the patients.