益生菌联合抗抑郁药物治疗女性肠易激综合征疗效观察

THE EFFICACY OF PROBIOTICS JOINT ANTIDEPRESSANT IN THE TREATMENT OF FEMALE WITH IRRITABLE BOWEL SYNDROME

目的观察益生菌制剂(枯草杆菌二联活菌胶囊)联合抗抑郁药物(氟哌噻吨美利曲辛片)对不同类型女性肠易激综合征患者的疗效。方法选择符合罗马Ⅲ诊断标准,伴有抑郁,焦虑状态的女性肠易激综合征患者194例,将患者根据症状分为腹泻型组与便秘型组,每组再随机分为观察组及对照组,常规给予调节胃肠道功能药物(马来酸曲美布汀片0.1g,3次/d),观察组在对照组基础上加用枯草杆菌二联活菌胶囊0.5g,3次/d及氟哌噻吨美利曲辛片早上,中午各0.5mg,疗程共4周,用药后对患者的症状改善情况、有效率、不良反应进行评估。结果腹泻组观察组症状明显改善,有效率明显提高(P<0.05),而便秘组症状有所改善,但有效率与对照组相比差异无统计学意义(P>0.05)。结论对伴有腹泻的肠易激综合征患者,益生菌制剂及抗抑郁药物联合可有效改善症状,值得在临床推广,但便秘型肠易激综合征患者疗效较差。

Objective To observe the clinical curative effect of probiotics （bacillus subtilis and enterococcus faecim） combined with antidepressants （flupentixol melitracen） on women with different types of irritable bowel syndrome. Methods According to the Roman Ⅲ diagnostic criteria, 194 cases of women diagnosed with irritable bowel syndrome were selected, who were also associated with depression, anxiety. They were divided into diarrhea and constipation groups. Each group was randomly divided into treatment group and control group. Every group was treated by regulation of gastrointestinal routinely （maleic acid trimebu- tine 0. 1g tid）, while the treatment groups were given Bacillus subtilis and Enterococcus faecim （0.5g tid） and Flupentixol Melitracen （0.5mg one time in the morning, noon） on the basis of the control group. After 4 weeks, the effect of the treatment in the patients symptoms, effective rate and adverse reactions were e- valuated. Results The symptoms of diarrhea treatment group improved significantly, and the effective rate were improved obviously （P〈0.05）. While the effective rate of the constipation group symptoms had no difference between the control group （P〉0.05）. Conclusion The combination of probiotic and antidepres- sants can effectively improve the symptoms of patients with irritable bowel syndrome in diarrhea type, while to the constipation type the curative effect is poorer.