摘要
目的:探讨小泛素相关修饰因子4(SUMO4)表达与甲状腺乳头状癌(PTC)发生发展的关系。方法:采用real-time PCR、Western blot及免疫组化等方法检测PTC和正常甲状腺组织中SUMO4的mRNA及蛋白表达情况,对比研究SUMO4蛋白表达与PTC及其临床病理特征的关系。结果:SUMO4的mRNA及蛋白表达量在PTC中均明显高于正常甲状腺组织(P<0.01)。结论:SUMO4在PTC的高表达提示其在PTC发生发展中扮演着重要的角色,可能与PTC发病的分子机制有关。
AIM： To discuss the relationship between small ubiquitin-related modifier 4（ SUMO4） expression and papillary thyroid carcinoma（ PTC）. METHODS： The mRNA and protein levels of SUMO4 in PTC and normal thyroid tissues were determined by the methods of real-time PCR,Western blot and immunohistochemistry. The relationship between SUMO4 expression and clinicopathologic parameters in PTC was evaluated. RESULTS： The results showed that both the mRNA and protein levels of SUMO4 expression in PTC were obviously higher than those in normal thyroid tissues（P〈0. 01）. CONCLUSION： The high level of SUMO4 expression in PTC suggests that SUMO4 plays an important role in PTC development and it is probably a molecular mechanism of PTC.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2015年第8期1422-1426,共5页
Chinese Journal of Pathophysiology
基金
2014年浙江省自然科学基金资助项目(No.Y14H160128)
