乌鲁木齐汉族和维吾尔族血清游离脂肪酸参考区间的确立

Establishment of the reference interval for serum free fatty acids of Han and Uyghur populations in Urmuqi

目的 确立新疆地区汉族和维吾尔族血清游离脂肪酸（FFA）参考区间。方法 根据纳入标准入选健康体检人员1 220例标本,其中汉族739例,男性381例,女性358例;维吾尔族481例,男性142例,女性339例;分为19~30岁组、31~50岁组、51~75岁组。参照美国临床实验室标准化委员会（CLSI）“临床实验室如何定义和确立参考区间（C28-A3）”方案,评价汉族、维吾尔族正常人群性别及年龄分组间血清FFA差异,确立参考区间。结果 汉族和维吾尔族男、女性受检者FFA浓度差异无统计学意义（P=0.636 4,P=0.377 6）;汉族、维吾尔族女性受检者FFA浓度差异无统计学意义（P=0.226 8）;维吾尔族男性受检者FFA浓度低于汉族,差异有统计学意义（P=0.047 0）;汉族各年龄组间FFA浓度比较差异无统计学意义;维吾尔族19~30岁组受检者血清FFA浓度较31~50岁组、51~75岁组低;总体维吾尔族受检者血清FFA浓度低于汉族;确立新疆本地区FFA参考区间：汉族为0.14~0.86mmol/L,维吾尔族为0.10~0.82mmol/L。结论 汉族、维吾尔族体检者血清FFA浓度有差异,需要建立乌鲁木齐地区FFA正常参考区间。

Objective Establish reference range for serum free fatty acid （FFA） of Han and Uyghur in Xin- jiang area. Methods 1 220 specimens from healthy physical examination personnel were included in our study based inclusion criteria. Among them, 739 samples consisted of 381 males and 358 females were from Han and 481 cases composed by 142 males and 339 females were Uyghurs. They were divided into three groups according to their age, that is 19-30, 31--0 and 51-75. The difference of serum free fatty acid （FFA） between Han and Uyhgurs with different age and gender, thus the reference range was estab- lished with reference to ＂How to define and establish the reference range of clinical laboratory （C28-A3）＂ plan of the clinical laboratory standardization committee （CLSI）. Results There is no significant difference of FFA results between genders （P =0.636 4,P =0.377 6）, females of Han and Uyghur （P =0.226 8）andHan people with different age . While the FFA results of Uyghur males is lower than Han males （P = 0.047 0）, the 19-30 years old group of Uyghur is lower than other two groups, generally, the FFA results of Uyghur is lower than Han. Thus, the reference ranges of FFA in Xinjiang were： 0.14-0.86 mmol/L for Han and 0.10~0.82 mmol/L for Uyghur. Conclusion There is difference between Han and Uyghur in FFA, Actions needed to establish normal Han and Uyghur reference interval of FFA in Urumqi.