依托考昔联合氨基葡萄糖治疗膝关节骨性关节炎的临床研究

Clinical study on Etoricoxib and Glucosamine to treat patients with knee osteoarthritis

目的探讨依托考昔联合氨基葡萄糖治疗中、重度膝关节骨性关节炎的临床疗效及其临床应用价值。方法将106例中、重度膝关节骨性关节炎患者随机分为对照组(单纯应用依托考昔)和治疗组(依托考昔+氨基葡萄糖),连续治疗4w。对两组患者治疗前后VAS评分及Lysholm评分变化进行统计学分析,并计算其临床总有效率。结果治疗4w后,两组患者VAS评分较治疗前明显降低,Lysholm评分均较治疗前明显升高(P均<0.05),治疗组的效果优于对照组;对照组总有效率为88.89%,治疗组总有效率为92.30%,差异有统计学意义(P<0.05)。结论依托考昔联合氨基葡萄糖治疗中、重度膝关节骨性关节炎临床疗效显著,患者疼痛缓解两组VAS评分相近,改善膝关节功能疗效优于单纯依托考昔。

Objective To observe clinical efficacy and value of Etoricoxib combined with glucosamine treat- ment of moderate to severe knee osteoarthritis. Methods 106 patients with moderate to severe osteoarthri- tis of the knee were randomly divided into control group （simple application of Etoricoxib） and treatment group （Etoricoxib＋Glucosamine）, continuous treatment 4 weeks. The statistical analysis was applied in the two groups of patients before and after treatment VAS score and Lysholm score changes, and the rates of total clinical effectiveness were calculated. Results After 4 weeks treatment, the two groups were sig- nificantly lower VAS scores, Lysholm score treatment group was significantly better than those of the control group, and the difference was statistically significant （P〈0.05）. Conclusion It showed that the clinically significant effects in Etoricoxib combined with Glucosamine treatment of moderate to severe knee osteoarthritis, relieve pain similar in both groups of patients, improve the efficacy of knee function better than Etoricoxib.