双歧杆菌联合早期微量喂养预防新生儿坏死性小肠结肠炎的研究

Clinical study of the effect of Bifidobacterium combined with early minimal enteral feeding on prevention of neonatal necrotizing enterocolitis

目的探讨双歧杆菌联合微量喂养预防新生儿坏死性小肠结肠炎的效果。方法选用2013年1月至2014年2月在我院出生的108例早期早产儿作为研究对象,分治疗组(n=56)和对照组(n=52),对照组采用早期微量喂养法。治疗组在对照组基础上加用双歧杆菌。结果对照组在住院期间发生NEC6例(11.54%),治疗组发生NEC 2例(3.57%),差异有统计学意义。与对照组比较,治疗组静脉营养持续时间、住院时间减少,出院体重较高,差异均有统计学意义;治疗组中发生新生儿高胆红素血症的例数明显减少,差异有统计学意义。结论新生儿在早期微量喂养基础上适当补充双歧杆菌,NEC发生率明显降低,严重程度减轻,同时可缩短静脉营养持续时间、住院时间,增加出院时体重,减少新生儿高胆红素血症的发生。

Objective To analyze the effect of bifidobacterium combined with early minimal enteral feeding on prevention of neonatal necrotizing enterocolitis. Methods One hundred and eight infants horned in our hospital were randomly divided into preventing group （n = 56） and control group （n= 52）. The control group was given minimal enteral feeding. The preventing group received bifidohacterium combined with early minimal enteral feeding. Results There were 6 cases （11.54 %） of NEC in the control group,while 2 cases（3.57% ） in the preventing group, the difference is statistical significance. The duration of intra- venous nutrition, the hospitalization time of the preventing group were decreased. Compared with the control group, the compli cation of hyperbilirubinemia of the preventing group was decreased, and the difference is statistical significance. Conclusion The prevention of probiotics combined with early minimal enteral feeding on infants decreased the incidence and severity of NEC,decreased the duration of parenteral nutrition, the hospitalization time and the incidence of hyperbilirubinemia, while in- creased the infanfs weight at discharged from hospital.