血筛ALT临界值变更对血液安全影响的分析

Analysis of the impact of ALT threshold changes during blood screening on blood safety

目的分析兰州地区血液筛查ALT临界值变更前后检测结果的变化情况,探讨ALT临界值变更对血液安全的影响。方法收集2010-2013年无偿献血者的血液检测结果,分析ALT临界值变更前后不合格率的变化情况和ALT异常与肝炎标志物的相关性。结果 ALT临界值变更后,单项ALT不合格率明显下降;ALT数值介于(40-50)U/L的标本经核酸检测,HBV DNA和HCV RNA结果均为阴性;ALT合格组与不合格组中肝炎标志物阳性率的差异无统计学意义。结论 HBV/HCV的感染不是献血者ALT异常的主要原因;结合核酸检测结果,本次血筛ALT临界值的变更不会对血液安全造成影响,同时降低了血液的报废率。

Objective To analyze the variation in blood screening results before and after changes in ALT threshold in Lanzhou,and to investigate the effects of ALT changes on blood safety indicators. Methods Blood test results of unpaid blood donors from 2010 to 2013 were collected. The changes in failure rates before and after ALT threshold changes and the correlation between abnormal ALT and hepatitis markers were analyzed. Results The individual ALT failure rate decreased after ALT indicator changed. When ALT values ranged between 40 u / L and 50 u / L samples in the nucleic acid detection,HBV DNA and HCV-RNA results were negative. The ALT hepatitis markers in the qualified and unqualified groups showed no statistically significant differences. Conclusion HBV or HCV infection do not constitute the main reason for ALT abnormalities. Combined with nucleic acid testing results,changes in ALT threshold during blood screening does not affect blood safety,while simultaneously reducing blood waste.