Th17/Treg细胞与自身免疫性葡萄膜炎的研究进展

Current researches of the relationship between Th17/Treg cells and autoimmune uveitis

葡萄膜炎是一组常见的由自身免疫紊乱导致的眼部炎症性致盲性眼病,现代研究认为主要是由CD4+T细胞介导产生。CD4+T细胞主要分为Th1,Th2,Th17和Treg细胞(CD4+CD25+Foxp3+调节性T细胞)四个亚群。以往研究主要集中在Th1,Th2细胞亚群,近年来研究表明,Th17细胞是诱导自身免疫性葡萄膜炎发病的主要原因,而Treg细胞是负向调控葡萄膜炎的主要因素。因此,Th17和Treg细胞在葡萄膜炎的发病及病程演变过程中发挥重要作用,本文就Th17细胞、Treg细胞与自身免疫性葡萄膜炎的相关研究进展进行综述。

Human autoimmune uveitis is a group of common ocular inflammatory diseases caused by autoimmune disorder. It is considered an inflammatory response dominated by CD4＋ T cells at present. It is well known that CD4＋ T cells are divided into four subsets including Th1, Th2, Th17 and Treg cells （CD4＋ CD25＋ Foxp3＋ regulatory T cells）. Previous studys have focused on Th1 and Th2 cells. Recent studys indicate that Th17 cells are the main factor of induction of uveitis while Treg cells are the main factor of negative regulation of uveitis. And they both play important roles in the onset and progression of uveitis. We give a review of current research in the relationship between Th17/Treg cells with autoimmune uveitis.