辅助生殖技术助孕与自然受孕双胎妊娠并发妊娠期肝内胆汁淤积症的临床分析

Clinical analysis on twin pregnancy with ICP of assisted reproductive techniques conception and natural conception

回顾性分析582例辅助生殖技术助孕与自然受孕双胎妊娠中妊娠期肝内胆汁淤积症(ICP)的发生情况及其对围产期并发症的影响。结果显示辅助生殖技术助孕双胎妊娠并发ICP为8.53%,自然受孕双胎妊娠并发ICP为16.98%,发生重度ICP的比例分别为22.73%、54.55%。辅助生殖技术助孕与自然受孕双胎妊娠并发ICP在围产期血清总胆汁酸、丙氨酸转移酶、门冬氨酸转移酶、入院孕周、分娩孕周、剖宫产率、Apgar评分、早产、胎膜早破、胎儿窘迫、产后24 h出血量方面比较,差异均无统计学意义。辅助生殖技术组双胎妊娠并发ICP的新生儿出生体重大于自然受孕组。辅助生殖技术助孕双胎妊娠并不增加ICP的发生率,围产期并发症无增加。

To analyse intrahepatic cholestasia of pregnancy （ICP） occurrence in 582 cases of twin pregnancy con- ceived by assisted reproductive techniques and natural conception retrospectively, and to analyse its influence on perinatal complications. The percentage in the group of assisted reproductive techniques twin pregnancies with ICP （ ART group） was 8.53% , which was 16.98% in the group of naturally conceived twin pregnancies with ICP（ nat- urally conceived group） , and the severity of ICP in ART group was 22.73% , which was 54.55% in the naturally conceived group. To compare the two groups in TBA, ALT, AST, hospitalized pregnant weeks, the weeks of delivery, the rate of cesarean section, the Apgar score, premature birth, premature rupture of membranes and fetal distress, 24-hour postpartum hemorrhage volume, there were no statistically significant differences. The neonatal weight of ART group was greater than the naturally conceived group. Twin pregnancies conceived by assisted repro- ductive technology did not increase the incidence of ICP. And there were no differences in complications of perinatal period.