摘要
目的:通过筛查发现宫颈上皮内瘤样病变及高危型HPV感染的人群并进行有效的防治、随访。方法:收集门诊接诊的患者3953例,行宫颈超薄液基细胞学检查(TCT),其中892例同时进行高危型HPV-DNA检测;宫颈CINⅠ以上的同时行阴道镜多点活检,根据细胞学及病理学诊断宫颈病变及病变程度,针对不同的病变程度进行治疗、随访。结果:宫颈癌及高度鳞状上皮内瘤变同时合并高危型HPV感染26例,感染率达100%,CINⅠ98例,其中96例合并高危型HPV感染;ASCUS126例,其中合并高危HPV感染87例,单纯高危型HPV感染10例。术后6个月回访HPV感染4例,ASCUS1例,CINⅠ1例;术后12个月回访,CIN已消退,未见异常,HPV全部转阴。结论:定期的TCT配合HPV-DNA检测对宫颈癌及癌前病变的早期发现、早期诊断、早期干预及治疗起决定性的作用。
Objective： To screen people with cervical intraepithelial neoplasia and HPV infection in order to offer proper treatment and follow-up.Method： 3953 out-patients were given cervical liquid based thin layer cell examination （TCT）, 892 of whom were tested with high-risk HPV-DNA at the same time.Patients whose grades were higher than Cervical CIN I also received colposcopic multiple biopsy.Treatments were offered according to the cytological and pathological diagnosis of cervical lesions and their lesion degree.Result： There were 26 patients with cervical cancer or high squamous intraepithelial neoplasia combined with high-risk HPV infection, the infection rate was 100%.There were 98 patients with CIN ] including 96 patients with high-risk HPV infection.126 patients got ASCUS, among them 87 patients were with high risk HPV infection.10 patients were only with high-risk HPV infection.After six months follow-up, there were four patients with HPV infection, one patient with ASCUS and one patient with CIN I .After twelve months follow-up, it showed that CIN had subsided and no abnormality was found.HPV turned negative.Conclusion： Regular TCT and HPV-DNA test play a decisive role in the early detection, diagnosis, intervention and treatment of cervical cancer and precancerous disease.
出处
《中国医学创新》
CAS
2015年第24期143-146,共4页
Medical Innovation of China
