摘要
目的:通过筛查发现宫颈上皮内瘤样病变及高危型HPV感染的人群并进行有效的防治、随访。方法:收集门诊接诊的患者3953例,行宫颈超薄液基细胞学检查(TCT),其中892例同时进行高危型HPV-DNA检测;宫颈CINⅠ以上的同时行阴道镜多点活检,根据细胞学及病理学诊断宫颈病变及病变程度,针对不同的病变程度进行治疗、随访。结果:宫颈癌及高度鳞状上皮内瘤变同时合并高危型HPV感染26例,感染率达100%,CINⅠ98例,其中96例合并高危型HPV感染;ASCUS126例,其中合并高危HPV感染87例,单纯高危型HPV感染10例。术后6个月回访HPV感染4例,ASCUS1例,CINⅠ1例;术后12个月回访,CIN已消退,未见异常,HPV全部转阴。结论:定期的TCT配合HPV-DNA检测对宫颈癌及癌前病变的早期发现、早期诊断、早期干预及治疗起决定性的作用。
Objective: To screen people with cervical intraepithelial neoplasia and HPV infection in order to offer proper treatment and follow-up.Method: 3953 out-patients were given cervical liquid based thin layer cell examination (TCT), 892 of whom were tested with high-risk HPV-DNA at the same time.Patients whose grades were higher than Cervical CIN I also received colposcopic multiple biopsy.Treatments were offered according to the cytological and pathological diagnosis of cervical lesions and their lesion degree.Result: There were 26 patients with cervical cancer or high squamous intraepithelial neoplasia combined with high-risk HPV infection, the infection rate was 100%.There were 98 patients with CIN ] including 96 patients with high-risk HPV infection.126 patients got ASCUS, among them 87 patients were with high risk HPV infection.10 patients were only with high-risk HPV infection.After six months follow-up, there were four patients with HPV infection, one patient with ASCUS and one patient with CIN I .After twelve months follow-up, it showed that CIN had subsided and no abnormality was found.HPV turned negative.Conclusion: Regular TCT and HPV-DNA test play a decisive role in the early detection, diagnosis, intervention and treatment of cervical cancer and precancerous disease.
出处
《中国医学创新》
CAS
2015年第24期143-146,共4页
Medical Innovation of China