探讨儿童咳嗽变异性哮喘的临床特征及峰流速评估作用

To Investigate the Clinical Characteristics and Assess the Role of the Peak Expiratory Flow Rate in Children with Cough Variant Asthma

为分析咳嗽变异性哮喘(CVA)儿童的临床特征,明确呼气峰流速值(PEF)日间变异率是否可以监测CVA向典型哮喘的转变。研究CVA患者90例,分为单纯CVA组和发展为典型哮喘组。比较两组患儿的临床资料及PEF日间变异率。结果显示:14.4%的CVA患儿发展为典型哮喘,在出现哮喘典型症状之前,PEF变异率明显增高。未规律吸入激素者显著高于吸入激素8周以上的CVA患者发展为哮喘的比例。因此,峰流速仪作为检测肺功能的手段,可以监测CVA向典型哮喘的转变。长期规范吸入激素治疗可减少CVA患者进展为典型哮喘。

To monitor the CVA to typical asthma by the peak expiratory flow （PEF） mutation rate. The 90 CVA children were observed and recorded of the basic clinical data including inducing factors, associated symptoms. They were confirmed typical symptoms. These children were divided into CVA group and asthma group. Two groups were compared by the clinical data and PEF. 14.4% children with CVA developed into the typical asthma.Before the appearance of the typical symptoms of asthma, PEF mutation rate increased. CVA children who did not regularly inhaled corticosteroids for more than 8 weeks were significantly higher than those who regularly inhaled corticosteroids for more than 8 weeks. The peak flow meter can monitor the CVA to typical asthma. Long term inhaled hormone can reduce CVA patients to typical asthma.