摘要
目的:观察胰岛素样生长因子1(insulin-like growth factor 1,IGF-1)在结直肠癌中的表达情况,评价其与结直肠癌血管生成指标及临床病理参数之间的关系.方法:选择于首都医科大学附属北京世纪坛医院经病理确诊的56例散发性结直肠癌患者病变组织,免疫组织化学染色观察IGF-1在结直肠癌组织的表达情况,CD34免疫组织化学染色后计数微血管密度(microvessel density,MVD).结果:IGF-1在结直肠癌与正常黏膜中高表达率分别为85.71%和35.00%(P<0.05),IGF-1的高表达与淋巴结转移明显相关(P<0.05).结直肠癌与正常黏膜的MVD值分别为35.55±7.78和8.76±2.67(P<0.05).IGF-1的表达强度与MVD呈正相关(P<0.05).结论:IGF-1在结直肠癌组织中高表达,并可能通过参与结直肠癌血管生成促进其进展.
AIM： To investigate the relationship between the expression of insulin-like growth factor 1 （IGF-1） and clinicopathological parameters, as well as tumor angiogenesis in colorectal cancer. METHODS： The expression of IGF-1 was detected using immunohistochemical method in 56 colorectal carcinoma and 20 normal colon tissues. Microvessel density （MVD） was counted by evaluating the expression of endothelial marker CD34. RESULTS： The positive rates of IGF-1 in colorectal carcinoma and normal mucosa were 85.71% and 35%, respectively. The expression of IGF-1 correlated with lymph node metastasis significantly （P 〈 0.05）. MVD values were 8.76±2.67 and 35.55 ± 7.78 in normal colon tissue and colorectal cancer, respectively. MVD correlated significantly with differentiation degree, invasion depth, Duke＇s stage and lymph node metastasis （P 〈 0.05 for all）. CONCLUSION： IGF-1 is highly expressed in colorectal adenocarcinorna and may be involved in the progression of colorectal cancer through enhancing tumor angiogenesis.
出处
《世界华人消化杂志》
CAS
2015年第21期3384-3389,共6页
World Chinese Journal of Digestology
基金
北京市教育委员会科技发展计划基金面上资助项目
No.KM201210025015
北京市卫生系统高层次卫生技术人才培养计划基金资助项目
No.2011RC1~~
