糖尿病性勃起障碍发病机制及治疗研究进展被引量：16

Advances in pathogenesis and medication of diabetes-induced erectile dysfunction

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摘要勃起功能障碍是糖尿病的重要并发症之一,其发病主要是由糖尿病性血管神经病变、内分泌改变及社会心理等因素共同作用的结果。目前治疗糖尿病性勃起障碍(DIED)的方法有多种,磷酸二酯酶-5抑制剂被作为治疗DIED的一线药物。随着对其发病机制的研究,血管生成素、睾酮补充以及传统中药也逐渐用于治疗DIED。另外,当药物治疗已无法收到效果时,阴茎假体植入手术也将会成为治疗DIED的选择之一。 Erectile dysfunction （ED） is a common distressing complication of diabetes mellitus, which is the result of diabetic neuropathy, vascular and endocrine changes and psychosocial factors. Currently, there are a variety of methods for treating diabetes-induced erectile dysfunction （DIED）. For example, phosphodiesterase type-5 inhibitors, as the first-line therapeutic options for diabetic men with ED, are used as first-line drugs to treat DIED. As a result of more studies on its pathogenesis, angiopoietin, testosterone supplements and traditional Chinese medicine have been used to treat DIED. In addition, if medication fails to achieve the desired result, penile prosthesis implant surgery will also be- come an option to treat DIED. This article summarizes related research progress.

作者周斌谢高宇齐敏友

机构地区浙江工业大学药学院药理学教研室.浙江杭州贵阳中医学院基础医学院.贵州贵阳

出处《中国药理学与毒理学杂志》 CAS CSCD 北大核心 2015年第4期626-632,共7页 Chinese Journal of Pharmacology and Toxicology

基金贵州省科技厅贵阳中医学院联合基金资助项目(2012LKZ7027)~~

关键词糖尿病勃起功能障碍糖尿病并发症 diabetes mellitus erectile dysfunction diabetes complications

分类号 R587.2 [医药卫生—内分泌]

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