灯盏细辛注射液对心肌缺血再灌注损伤的保护作用

Effect of Erigeron breviscapus injection on myocardial ischemia reperfusion injury

目的:观察灯盏细辛注射液对急性心肌梗死(AMI)介入治疗后缺血再灌注损伤心肌的保护作用。方法:选取因AMI行冠脉介入治疗(PCI)患者60例,术后随机分为研究组与对照组,各30例,2组患者PCI术后均给予常规处理,包括ACEI或ARB、硝酸酯类、低分子量肝素、肠溶阿司匹林、氯毗格雷、β-受体阻滞剂及他汀类药物。研究组在常规处置的基础上加用灯盏细辛静脉滴注,每次60mL,每日1次;对照组PCI术后仅给予常规治疗。对比2组患者手术前后血清IL-6、TNF-α、SOD、MDA及NO等指标的变化。结果:研究组术后血清IL-6、TNF-α水平显著低于对照组(均P<0.05);研究组术后血清SOD、NO显著高于对照组(P<0.05),血清MDA显著低于对照组(P<0.05)。结论:灯盏细辛注射液可有效清除心肌缺血再灌注损伤患者氧自由基,抑制炎症反应,减轻心肌损伤程度,对心肌缺血再灌注损伤具有显著的保护作用。

Objective：To observe the effect of Erigeron breviscapus injection on acute myocardial ischemia（AMI）reperfusion injury after interventional therapy.Methods：A total of 60 AMI patients with percutaneous coronary intervention（PCI）were selected,and randomly divided into observation group and control group by half.All patients were treated with conventional treatment after PCI,including ACEI or ARB,nitrates,low molecular weight heparin,enteric coated aspirin,clopidogrel,β-receptor blocker and statins.Patients in observation group were treated with venous injection of Erigeron breviscapus,60 mL every time,one time daily.IL-6,TNF-α,SOD,MDA and NO were detected and compared.Results：Compared with control group,levels of IL-6,TNF-αand MD in observation group were significantly lower（P〈0.05）,SOD and NO levels were significantly higher（P〈0.05）.Conclusions：Erigeron breviscapus injection can effectively clear oxygen radical of AMI patients with reperfusion injury,inhibit inflammation reaction,alleviate injury and has significant protection function.